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          <title>Life Sciences IT Connect Newsletter</title>
          <link>http://lifesciencesinsight.com/</link>
          <description>News and commentary for technology leaders in the life sciences, pharmaceutical and bio tech community</description>
          <copyright>8/1/2010 4:07:17 AM</copyright>
          <pubDate>Sun, 01 Aug 2010 08:07:17 GMT</pubDate>
          <atom:link href="http://cms.crosstechpartners.com/_RSS.ashx?Group=CTP&amp;Id=6f107608-3e7f-4ebe-aff7-472496fa9f9e" rel="self" type="application/rss+xml" />
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               <title>2009: The Year Pharma Learned to Love Itself</title>
               <description>2007 was the year that pharma fell in love with biologics, but as the saying goes, you can't love someone else before you love yourself. 2009 was the year pharma fell in love with itself.&lt;br /&gt;&lt;br /&gt;The major consolidation started in January, with Pfizer announcing its acquisition of Wyeth. Merck announced its nuptials with Schering-Plough a few months later.</description>
               <crossTech:Body>&lt;p&gt;&lt;span id="lblBody"&gt;&lt;p&gt;&lt;span&gt;2007 was the year that pharma &lt;a href="http://www.fool.com/investing/high-growth/2007/12/20/2007-the-year-pharma-fell-in-love-with-biologics.aspx"&gt;fell in love with biologics&lt;/a&gt;,but as the saying goes, you can't love someone else before you loveyourself. 2009 was the year pharma fell in love with itself.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;The major consolidation started in January, with &lt;strong&gt;Pfizer&lt;/strong&gt;   &lt;span class="ticker"&gt;(NYSE: &lt;a href="http://caps.fool.com/Ticker/PFE.aspx" class="qsAdd qs-source-isssitthv0000001"&gt;PFE&lt;/a&gt;)&lt;/span&gt; announcing its acquisition of Wyeth. &lt;strong&gt;Merck&lt;/strong&gt;   &lt;span class="ticker"&gt;(NYSE: &lt;a href="http://caps.fool.com/Ticker/MRK.aspx" class="qsAdd qs-source-isssitthv0000001"&gt;MRK&lt;/a&gt;)&lt;/span&gt; announced its nuptials with Schering-Plough a few months later.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;There were still some marriages with biotech. Roche &lt;a href="http://www.fool.com/investing/high-growth/2009/03/12/2-suitors-are-better-than-1.aspx"&gt;closed the deal for&lt;/a&gt; Genentech in 2009, but the courtship started in 2008. Besides, they were already &lt;a href="http://www.fool.com/investing/high-growth/2008/07/21/roche-wants-to-buy-genentech-again.aspx"&gt;married once&lt;/a&gt; before, &amp;nbsp;and Genentech already had a ring on its finger, considering Roche owned 66% of the company.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;&lt;strong&gt;What consolidation offers&lt;/strong&gt;&lt;br /&gt;Mergers in andof themselves aren't necessarily a bad thing. For instance, you onlyhave to pay one CEO. Drug reps can be more efficient by pushing drugsfrom both companies to doctors. Adding up the spare manufacturingcapacity between the two companies could result in the need for oneless plant. In all, the potential to increase efficiency is certainlythere.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;That's been the strategy with &lt;strong&gt;Johnson &amp;amp; Johnson&lt;/strong&gt;   &lt;span class="ticker"&gt;(NYSE: &lt;a href="http://caps.fool.com/Ticker/JNJ.aspx" class="qsAdd qs-source-isssitthv0000001"&gt;JNJ&lt;/a&gt;)&lt;/span&gt; and &lt;strong&gt;Abbott Labs'&lt;/strong&gt;   &lt;span class="ticker"&gt;(NYSE: &lt;a href="http://caps.fool.com/Ticker/ABT.aspx" class="qsAdd qs-source-isssitthv0000001"&gt;ABT&lt;/a&gt;)&lt;/span&gt; bolt-on acquisitions. Each company has increased earnings faster than revenue by increasing its own efficiency.&lt;/span&gt;&lt;/p&gt;&lt;table cellspacing="0" class="ed-table"&gt;    &lt;tbody&gt;        &lt;tr&gt;            &lt;th&gt;            &lt;p style="text-align: center;"&gt;            &lt;strong&gt;Company&lt;/strong&gt;            &lt;/p&gt;            &lt;/th&gt;            &lt;th&gt;            &lt;p style="text-align: center;"&gt;            &lt;strong&gt;Five-year annualized revenue growth rate&lt;/strong&gt;            &lt;/p&gt;            &lt;/th&gt;            &lt;th&gt;            &lt;p style="text-align: center;"&gt;            &lt;strong&gt;Five-year annualized growth rate of net income&lt;/strong&gt;            &lt;/p&gt;            &lt;/th&gt;        &lt;/tr&gt;        &lt;tr&gt;            &lt;td&gt;            &lt;p&gt;Johnson &amp;amp; Johnson&lt;/p&gt;            &lt;/td&gt;            &lt;td&gt;            &lt;p&gt;5.7%&lt;/p&gt;            &lt;/td&gt;            &lt;td&gt;            &lt;p&gt;6.9%&lt;/p&gt;            &lt;/td&gt;        &lt;/tr&gt;        &lt;tr&gt;            &lt;td&gt;            &lt;p&gt;Abbott&lt;/p&gt;            &lt;/td&gt;            &lt;td&gt;            &lt;p&gt;9.6%&lt;/p&gt;            &lt;/td&gt;            &lt;td&gt;            &lt;p&gt;12.4%&lt;/p&gt;            &lt;/td&gt;        &lt;/tr&gt;    &lt;/tbody&gt;&lt;/table&gt;&lt;p&gt;&lt;span class="smalltext"&gt;Source: Capital IQ, a division of Standard &amp;amp; Poor's.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;But those acquisitions took place on a much &lt;a href="http://www.fool.com/investing/value/2009/02/24/pfizer-diversified-dreams-dubious-decisions.aspx"&gt;smaller scale&lt;/a&gt;.Johnson &amp;amp; Johnson's largest was its $16.6 billion acquisition ofPfizer's consumer health-care division in 2006. For Abbott, it was a $7billion acquisition of BASF's pharmaceutical business. When you getreally big mergers -- Wyeth's price tag was $68 billion -- it can beharder to make the integrations work.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;&lt;strong&gt;What consolidation doesn't offer&lt;/strong&gt;&lt;br /&gt;Mybiggest problem with large drug mergers is that research anddevelopment -- the very thing drug companies need to overcome lostrevenue from drugs going off-patent -- doesn't seem to scale very well.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;Part of the problem is just a size thing. Getting a new drug approved at a midsized drug company like &lt;strong&gt;Gilead Sciences&lt;/strong&gt; or &lt;strong&gt;Celgene&lt;/strong&gt;   &lt;span class="ticker"&gt;(Nasdaq: &lt;a href="http://caps.fool.com/Ticker/CELG.aspx" class="qsAdd qs-source-isssitthv0000001"&gt;CELG&lt;/a&gt;)&lt;/span&gt; can &lt;a href="http://www.fool.com/investing/high-growth/2007/05/17/start-making-67000-today.aspx"&gt;add a lot of value&lt;/a&gt;, but for companies like Merck and Pfizer, it takes a lot to move the revenue needle.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;The bigger problem I see is a cultural difference between a smallstruggling development-stage drugmaker and a large pharmaceuticalgiant. Researchers at the former have a lot more incentive to discovernew drugs -- individual contributions have a larger effect on thecompany's value, and therefore on stock options.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;&lt;strong&gt;What to look for in 2010 and beyond&lt;/strong&gt;&lt;br /&gt;While anything is possible, I wouldn't expect much more consolidation of major drugmakers. &lt;strong&gt;Eli Lilly&lt;/strong&gt;   &lt;span class="ticker"&gt;(NYSE: &lt;a href="http://caps.fool.com/Ticker/LLY.aspx" class="qsAdd qs-source-isssitthv0000001"&gt;LLY&lt;/a&gt;)&lt;/span&gt; and &lt;strong&gt;sanofi-aventis&lt;/strong&gt;have both said they'd rather focus on small acquisitions andpartnerships than a large acquisition. Besides, there aren't that manyleft to acquire. At a $50 billion market cap, &lt;strong&gt;Bristol-Myers Squibb&lt;/strong&gt;   &lt;span class="ticker"&gt;(NYSE: &lt;a href="http://caps.fool.com/Ticker/BMY.aspx" class="qsAdd qs-source-isssitthv0000001"&gt;BMY&lt;/a&gt;)&lt;/span&gt; is about the right size for a large acquisition, but it seems to be more of an acquirer than a target.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;For Merck and Pfizer to make the ever-larger-pharmaceutical-companymodel work, they'll going to have to shift away from drug discovery andtoward marketing. They can use the cash they generate to license oracquire drugs from smaller drug companies and focus on what they dobest: usher drugs through clinical trials and regulatory approvals, andget them into the hands of patients&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;Unfortunately, with the long lag time in drug development, it may take years to know whether pharma has gotten mergers &lt;a href="http://www.fool.com/investing/value/2009/12/04/3-more-value-traps-to-avoid-right-now.aspx"&gt;right&lt;/a&gt; this time.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;Been in a coma for the last year? Here's a look at some of our coverage of drug mergers from 2009:&lt;/span&gt;&lt;/p&gt;&lt;ul&gt;    &lt;span&gt;    &lt;li&gt;    &lt;a href="http://www.fool.com/investing/dividends-income/2009/01/26/deja-vu-all-over-again.aspx"&gt;Deja Vu All Over Again&lt;/a&gt;    &lt;/li&gt;    &lt;li&gt;    &lt;a href="http://www.fool.com/investing/general/2009/02/09/just-say-no-to-drug-company-mergers.aspx"&gt;Just Say No to Drug Company Mergers&lt;/a&gt;    &lt;/li&gt;    &lt;li&gt;    &lt;a href="http://www.fool.com/investing/value/2009/02/24/pfizer-diversified-dreams-dubious-decisions.aspx"&gt;Pfizer: Diversified Dreams, Dubious Decisions&lt;/a&gt;    &lt;/li&gt;    &lt;li&gt;    &lt;a href="http://www.fool.com/investing/general/2009/03/09/merck-schering-trumps-pfizer-wyeth.aspx"&gt;Merck-Schering Trumps Pfizer-Wyeth&lt;/a&gt;    &lt;/li&gt;    &lt;li&gt;    &lt;a href="http://www.fool.com/investing/general/2009/03/24/drugmakers-diversify-again.aspx"&gt;Drugmakers Diversify -- Again&lt;/a&gt;    &lt;/li&gt;    &lt;li&gt;    &lt;a href="http://www.fool.com/investing/dividends-income/2009/05/21/not-so-fast-schering-er-merck-er-whoever-you-are.aspx"&gt;Not So Fast, Schering ... er, Merck ... er, Whoever You Are&lt;/a&gt;    &lt;/li&gt;    &lt;li&gt;    &lt;a href="http://www.fool.com/investing/general/2009/07/30/merck-sanofi-and-scherings-love-triangle.aspx"&gt;Merck, Sanofi, and Schering's Love Triangle&lt;/a&gt;    &lt;/li&gt;    &lt;li&gt;    &lt;a href="http://www.fool.com/investing/dividends-income/2009/09/01/merck-to-bride-leave-the-jewelry-at-home.aspx"&gt;Merck to Bride: Leave the Jewelry at Home&lt;/a&gt;    &lt;/li&gt;    &lt;li&gt;    &lt;a href="http://www.fool.com/investing/general/2009/10/27/pfizers-and-mercks-loss-is-these-companies-gain.aspx"&gt;Pfizer's and Merck's Loss Is These Companies' Gain&lt;/a&gt;    &lt;/li&gt;    &lt;li&gt;And finally, we bid adieu in &lt;a href="http://www.fool.com/investing/general/2009/10/15/an-ode-to-wyeth.aspx"&gt;An Ode to Wyeth&lt;/a&gt; and one to &lt;a href="http://www.fool.com/investing/general/2009/11/04/an-ode-to-schering-plough.aspx"&gt;Schering-Plough&lt;/a&gt;.&lt;/li&gt;    &lt;/span&gt;&lt;/ul&gt;    &lt;/span&gt;    &lt;/p&gt;    &lt;p&gt;By: &lt;em&gt;&lt;a target="_blank" href="http://www.fool.com/investing/dividends-income/2009/12/18/2009-the-year-pharma-learned-to-love-itself.aspx"&gt;Brian Orelli&lt;/a&gt;&lt;/em&gt; for &lt;a href="http://www.fool.com"&gt;The Motley Fool&lt;/a&gt;.&lt;/p&gt;</crossTech:Body>
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               <dc:creator>Brian Orelli</dc:creator>
               <link>http://lifesciencesinsight.com/article.html?a=2009:-The-Year-Pharma-Learned-to-Love-Itself</link>
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               <pubDate>Tue, 22 Dec 2009 05:00:00 GMT</pubDate>
               <crossTech:date>12/22/2009</crossTech:date>
               <category>Lead</category>
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               <title>CRM/SFA: Guidelines for System Selection</title>
               <description>Life science companies face significant challenges around the sales and marketing environment, as OIG regulations, the Physician Payments Sunshine Act, the new PhRMA code, and state-by-state mandates quickly reshape operating guidelines. In response, some companies are evaluating enhanced CRM,/SFA solutions to increase their sales and marketing capabilities and promotional competitiveness.</description>
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               <dc:creator>Eric Newmark</dc:creator>
               <link>http://idc-insights-community.com/posts/5af964ebbd</link>
               <guid isPermaLink="false">http://idc-insights-community.com/posts/5af964ebbd/2723e8ca-8acf-47dc-b76c-1a28349ec1f4</guid>
               <pubDate>Tue, 22 Dec 2009 05:00:00 GMT</pubDate>
               <crossTech:date>12/22/2009</crossTech:date>
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               <title>Tech glitterati strut DNA online</title>
               <description>Ten DNA-sequenced volunteers are posting this most private information online, unprotected. You'll recognize some of them by reputation, if not their DNA: pioneering technologist Esther Dyson, and high-ranking individuals from the tech/biotech industries and academia.</description>
               <crossTech:Body>&lt;div class="content"&gt;&lt;p&gt;Ten DNA-sequenced volunteers areposting this most private information online, unprotected. You'llrecognize some of them by reputation, if not their DNA: pioneeringtechnologist Esther Dyson, and high-ranking individuals from thetech/biotech industries and academia.&lt;/p&gt;&lt;p&gt;They are baring all, so to speak, mainly to see what happens. GeorgeChurch, a geneticist at Harvard Medical School, is behind the exposure.He, Dyson and eight others will post not just their DNA, but alsomedical records and descriptions of their physical traits, says &lt;em&gt;Forbes&lt;/em&gt;.&lt;/p&gt;&lt;p&gt;It's an effort called the Personal Genome Project, in which thevolunteers will relate the experience of having such personalinformation publicly available. Researchers want to determine the risksof DNA exposure, and learn how to develop software capable of managinghuman-scale DNA data volumes.&lt;/p&gt;&lt;p&gt;The ten volunteers are just the beginning. Researchers are in theprocess of recruiting the first 10,000 volunteers, on their way to100,000 from the general public.&lt;/p&gt;&lt;p&gt;- read the &lt;em&gt;Forbes&lt;/em&gt; &lt;a href="http://www.forbes.com/2009/12/12/dyson-digerati-voxiva-intelligent-investing-space_2.html"&gt;article&lt;/a&gt;&lt;br /&gt;- check out the project &lt;a href="http://www.personalgenomes.org/"&gt;Internet site&lt;/a&gt;&lt;br /&gt;- here are one volunteer's&amp;nbsp;&lt;a href="http://snp.med.harvard.edu/samples/PGP1_-_CGI"&gt;annotation results&lt;/a&gt;&lt;br /&gt;- see the intro &lt;a href="http://www.youtube.com/watch?v=mVZI7NBgcWM"&gt;video&lt;/a&gt;&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Related Articles:&lt;br /&gt;&lt;/strong&gt;&lt;a target="_parent" href="http://www.fiercebiotechresearch.com/story/genetics-research-next-big-hobby/2009-05-11"&gt;Is genetics research the next big hobby?&lt;/a&gt;&lt;br /&gt;&lt;a href="http://www.fiercebiotechresearch.com/story/complete-genomics-plots-5-000-dna-scanning/2008-12-17"&gt;Complete Genomics plots $5,000 DNA scanning&lt;/a&gt;&lt;br /&gt;&lt;a href="http://www.fiercebiotechresearch.com/story/start-offer-genome-sequencing-bargain-rate/2008-10-07-0"&gt;Start-up to offer genome sequencing at bargain rate&lt;/a&gt;&lt;br /&gt;&lt;a href="http://www.fiercebiotechresearch.com/story/new-genetic-map-used-advance-drug-research/2008-09-09"&gt;New genetic map used to advance drug research&lt;/a&gt;&lt;/p&gt;&lt;p&gt;&lt;a href="http://www.fiercebiotechresearch.com/story/new-genetic-map-used-advance-drug-research/2008-09-09"&gt;&lt;br /&gt;&lt;/a&gt;&lt;/p&gt;&lt;/div&gt;&lt;p&gt;By: &lt;em&gt;&lt;a href="http://www.fiercebiotechit.com/story/tech-glitterati-strut-dna-online/2009-12-19" target="_blank"&gt;George Miller&lt;/a&gt;&lt;/em&gt; for &lt;a href="http://www.fiercebiotechit.com/"&gt;&lt;img alt="Tech Watch" src="http://www.fiercebiotechit.com/public/logos/fiercebiotechit245.gif" style="border-style: solid; border-width: 0px;" /&gt;&lt;/a&gt;.&lt;/p&gt;</crossTech:Body>
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               <dc:creator>George Miller</dc:creator>
               <link>http://lifesciencesinsight.com/article.html?a=Tech-glitterati-strut-DNA-online</link>
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               <pubDate>Tue, 22 Dec 2009 05:00:00 GMT</pubDate>
               <crossTech:date>12/22/2009</crossTech:date>
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               <title>Life on the Edge - Filling the LS Revenue Gap on a Throw of the Dice</title>
               <description>The life science industry continues to move forward as it tries desperately to fill expected loss of revenue from drug blockbusters over the next several years.  Major M&amp;amp;A between mega pharmaceutical companies promises to restore profitability through increased operational efficiency, although this approach can only hope to maintain a somewhat proportionate rate of return at a lower combined revenue level.  Acquisitions of smaller biotechnology companies are a higher risk bet on the success of drugs in the pipeline, paid for at a premium that is likely to only get higher moving forward.  In all cases, the prolonged development and approval process guarantee that bets made today will not pay off for at least a few years at best and never, at worst.  Are we in desperate times in the industry or simply moving from one business model to the next?</description>
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               <dc:creator>Alan S. Louie</dc:creator>
               <link>http://idc-insights-community.com/posts/847c393671</link>
               <guid isPermaLink="false">http://idc-insights-community.com/posts/847c393671/493cfd4f-525e-433f-a53b-c65235d931fe</guid>
               <pubDate>Tue, 22 Dec 2009 05:00:00 GMT</pubDate>
               <crossTech:date>12/22/2009</crossTech:date>
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               <title>First cancer genome sequences reveal how mutations lead to disease</title>
               <description>Scientists have reconstructed the biological history of two types of cancer in a genetic tour de force that promises to transform medical treatment of the disease.&lt;br /&gt;&lt;br /&gt;The feat, a world first, lays bare every genetic mutation the patients have acquired over their lifetimes that eventually caused healthy cells in their bodies to turn into tumours.</description>
               <crossTech:Body>&lt;p&gt;Scientists have reconstructed the biological history of two types of &lt;a title="More from guardian.co.uk on Cancer" href="http://www.guardian.co.uk/science/cancer"&gt;cancer&lt;/a&gt; in a genetic tour de force that promises to transform medical treatment of the disease.&lt;/p&gt;&lt;p&gt;Thefeat, a world first, lays bare every genetic mutation the patients haveacquired over their lifetimes that eventually caused healthy cells intheir bodies to turn into tumours.&lt;/p&gt;&lt;p&gt;The procedure gives doctors aprofound insight into the biological causes of a patient's cancer andmarks a major milestone in progress towards personalised anticancertherapies and strategies to prevent the disease.&lt;/p&gt;&lt;p&gt;"This is areally fundamental moment in the history of cancer research. We havenever seen cancer revealed in this way before," said Mike Stratton, aco-leader of the &lt;a title="Cancer Genome Project at the Wellcome Trust Sanger Institute" href="http://www.sanger.ac.uk/genetics/CGP/"&gt;Cancer Genome Project at the Wellcome Trust Sanger Institute&lt;/a&gt; near Cambridge.&lt;/p&gt;&lt;p&gt;The researchers took diseased cells from &lt;a href="http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08658.html"&gt;a 45-year-old man with a type of skin cancer called malignant melanoma,&lt;/a&gt; and from a 55-year-old man with small cell &lt;a title="More from guardian.co.uk on Lung cancer" href="http://www.guardian.co.uk/lifeandstyle/lung-cancer"&gt;lung cancer&lt;/a&gt;.They then used advanced genetic sequencing machines to read the fullgenomes of both the cancer cells and healthy tissues taken from thesame patients.&lt;/p&gt;&lt;p&gt;By comparing the genetic makeup of the diseasedand healthy cells, the scientists created catalogues of all themutations found only in the cancerous tissues. Most of these geneticglitches are harmless, but every once in a while a mutation causesmajor damage that pushes a cell closer to becoming cancerous.&lt;/p&gt;&lt;p&gt;Thescientists focused on skin and lung cancer because the environmentalcauses are well known. Most melanomas are triggered by overexposure toultraviolet rays in sunlight as a child, while almost all small celllung cancer is caused by &lt;a title="More from guardian.co.uk on Smoking" href="http://www.guardian.co.uk/lifeandstyle/smoking"&gt;smoking&lt;/a&gt;.&lt;/p&gt;&lt;p&gt;In the case of the &lt;a href="http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08629.html"&gt;lung cancer patient&lt;/a&gt;,scientists discovered 23,000 mutations that were exclusive to thediseased cells. Almost all were caused by the 60 or so chemicals incigarette smoke that stick to DNA and deform it. "We can say that onemutation is fixed in the genome for every 15 cigarettes smoked," saidPeter Campbell, who led the lung cancer part of the study. "That isfrightening because many people smoke a packet a day."&lt;/p&gt;&lt;p&gt;Lungcancer accounts for one in seven deaths in the UK and is almostuntreatable. Fewer than 10% of patients in the UK survive more thanfive years after being diagnosed. The risk of developing the diseasefalls dramatically in smokers who have quit for more than 10 years.&lt;/p&gt;&lt;p&gt;Genetic sequencing of the skin cancer cells revealed 33,000 mutations caused by exposure to direct sunlight.&lt;/p&gt;&lt;p&gt;Humanshave 23 pairs of chromosomes that carry all of our genetic material inthe form of three billion pairs of letters. In both patients,scientists saw a variety of mutations. The most common were pointmutations, which flip one letter of the genetic code into another. Morecomplex mutations involved missing or extra sequences of DNA.Occasionally, chromosomes had broken apart or fused together in thewrong way.&lt;/p&gt;&lt;p&gt;"It's like doing archaeological excavation. You've gottraces and imprints of all these processes that have been operative fordecades before the cancer arose," said Stratton. The work is reportedin &lt;a href="http://www.nature.com/nature/journal/vaop/ncurrent/index.html"&gt;two studies published in the journal Nature&lt;/a&gt;.&lt;/p&gt;&lt;p&gt;Therapid advance of genetic technology is likely to make the technique aroutine procedure for cancer patients within 10 years. The SangerInstitute scientists costed the procedure at $100,000 per person a fewmonths ago, but they expect that to fall to $20,000 in the next 18months.&lt;/p&gt;&lt;p&gt;"In the long term, every cancer patient will have thisdone in a clinically relevant timeframe, so in the six weeks it takesto be seen, biopsied and taken into the clinic," said Stratton.&lt;/p&gt;&lt;p&gt;Theresearch is the first to emerge from a global consortium that isanalysing the genetic makeup of 50 different types of cancer. The10-year project will help cancer specialists unravel the particularmutations that drive each variety of tumour.&lt;/p&gt;&lt;p&gt;By understanding thegenetic flaws behind common cancers, scientists hope to develop morepowerful and precise anti-cancer drugs. In the near term, researchersexpect to develop blood tests that pick up signs that a cancer isreturning in patients who have already had surgery or chemotherapy.&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;By: &lt;em&gt;&lt;a href="http://www.guardian.co.uk/science/2009/dec/16/cancer-genome-sequences-genetic-mutations" target="_blank"&gt;Ian Sample&lt;/a&gt;&lt;/em&gt; for &lt;a href="http://www.guardian.co.uk"&gt;&lt;img alt="Tech Watch" src="http://static.guim.co.uk/static/83728/zones/news/images/logo.gif" style="border-style: solid; border-width: 0px;" /&gt;&lt;/a&gt;.&lt;/p&gt;</crossTech:Body>
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               <dc:creator>Ian Sample</dc:creator>
               <link>http://lifesciencesinsight.com/article.html?a=First-cancer-genome-sequences-reveal-how-mutations-lead-to-disease</link>
               <guid isPermaLink="false">http://lifesciencesinsight.com/article.html?a=First-cancer-genome-sequences-reveal-how-mutations-lead-to-disease/7e787bb9-499b-46b1-a18b-2cb5ab60bba6</guid>
               <pubDate>Tue, 22 Dec 2009 05:00:00 GMT</pubDate>
               <crossTech:date>12/22/2009</crossTech:date>
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               <title>Epigenetics specialists plan to edit the 'book of life'</title>
               <description>The Washington Post weighs in today with a detailed look at the surge of new research work that is going into epigenetics, a field that has already spawned a string of new biotechs and promises to deliver many more.</description>
               <crossTech:Body>&lt;div class="content"&gt;&lt;p&gt;&lt;em&gt;The Washington Post&lt;/em&gt; weighs intoday with a detailed look at the surge of new research work that isgoing into&amp;nbsp;epigenetics, a field that has already spawned a string&amp;nbsp;ofnew biotechs and promises to deliver many more.&lt;/p&gt;&lt;p&gt;To illustrate the potential of&amp;nbsp;epigenetics, the &lt;em&gt;Post&lt;/em&gt;&amp;nbsp;introducesus to two mice with identical DNA. One is brown and healthy while theother is&amp;nbsp;yellow, obese and suffering from diabetes.&amp;nbsp;Both live in thelab of Duke University's Randy Jirtle, who manipulated the epigenomethat can either turn on or shut down a gene. Jirtle&amp;nbsp;sees epigeneticsplaying the role of software, which is required to tell the body'sgenome hardware what to do.&lt;/p&gt;&lt;p&gt;The NIH is already a big believer in the field. It has earmarked$190 million to fund&amp;nbsp;new research work in epigenetics. And it'stargeting a wide array of specialties, including cancer, Alzheimer'sdisease, autism, bipolar disorder, schizophrenia, asthma, kidneydisease, glaucoma, muscular dystrophy and more.&lt;/p&gt;&lt;p&gt;"I've got goose bumps right now talking about it,"&amp;nbsp;Jirtle tells the &lt;em&gt;Post&lt;/em&gt;. "You're looking at the book of life, how it's read and how you can change it."&lt;/p&gt;&lt;p&gt;- check out the &lt;em&gt;Post&lt;/em&gt; &lt;a href="http://www.washingtonpost.com/wp-dyn/content/article/2009/12/14/AR2009121402894.html"&gt;story&lt;/a&gt;&amp;nbsp;&amp;nbsp;&amp;nbsp;&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Related Articles:&lt;br /&gt;&lt;/strong&gt;&lt;a href="http://www.fiercebiotech.com/story/glaxo-inks-375m-epigenetics-deal-supergen/2009-10-26"&gt;Glaxo inks $375M epigenetics deal with SuperGen&lt;/a&gt;&lt;br /&gt;&lt;a href="http://www.fiercebiotech.com/story/millennium-s-levin-uses-golden-touch-to-fund-start-up/2008-04-29"&gt;Millennium's Levin uses golden touch to fund start-up&lt;/a&gt;&lt;/p&gt;&lt;p&gt;&lt;a href="http://www.fiercebiotech.com/story/millennium-s-levin-uses-golden-touch-to-fund-start-up/2008-04-29"&gt;&lt;br /&gt;&lt;/a&gt;&lt;/p&gt;&lt;/div&gt;&lt;p&gt;By: &lt;em&gt;&lt;a href="http://www.fiercebiotechresearch.com/story/epigenetics-specialists-plan-edit-book-life/2009-12-15" target="_blank"&gt;John Carroll&lt;/a&gt;&lt;/em&gt; for &lt;a href="http://www.fiercebiotechresearch.com/"&gt;&lt;img alt="Tech Watch" src="http://www.fiercebiotechresearch.com/public/logos/fiercebiotechresearch245.gif" style="border-style: solid; border-width: 0px;" /&gt;&lt;/a&gt;.&lt;/p&gt;</crossTech:Body>
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               <dc:creator>John Carroll</dc:creator>
               <link>http://lifesciencesinsight.com/article.html?a=Epigenetics-specialists-plan-to-edit-the-'book-of-life'</link>
               <guid isPermaLink="false">http://lifesciencesinsight.com/article.html?a=Epigenetics-specialists-plan-to-edit-the-'book-of-life'/c0a4b22c-2c97-49c9-9759-b43afe38ad5f</guid>
               <pubDate>Tue, 22 Dec 2009 05:00:00 GMT</pubDate>
               <crossTech:date>12/22/2009</crossTech:date>
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               <title>The FDA, Big Pharma, and Social Media: What's the Right Rx?</title>
               <description>Last week the FDA held a hearing to begin a dialogue with the American public on the question of what level of online engagement is acceptable for healthcare companies to have with their customers. In other words, should the FDA make sure Merck's tweets are accurate?</description>
               <crossTech:Body>&lt;span class="Apple-style-span" style="word-spacing: 0px; font: medium 'times new roman'; text-transform: none; color: #000000; text-indent: 0px; white-space: normal; letter-spacing: normal; border-collapse: separate; orphans: 2; widows: 2; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px"&gt;&lt;span class="Apple-style-span" style="font-size: 12px; font-family: arial, helvetica, sans-serif"&gt;&lt;p style="line-height: 1.6em"&gt;Last week the FDA held a hearing to begin a dialogue with the American public on the question of&lt;span class="Apple-converted-space"&gt;&lt;/span&gt;&lt;a href="http://slatest.slate.com/id/2235551/entry/10/" style="color: rgb(179,8,56); text-decoration: none"&gt;what level of online engagement is acceptable&lt;/a&gt;&lt;span class="Apple-converted-space"&gt;&lt;/span&gt;for healthcare companies to have with their customers. In other words, should the FDA make sure Merck's tweets are accurate?&lt;/p&gt;&lt;p style="line-height: 1.6em"&gt;I view this as a simple issue made difficult by a regulated marketplace.&lt;/p&gt;&lt;p style="line-height: 1.6em"&gt;The healthcare industry has conducted the clinical trials and knows each drug or device inside and out. They are the world's experts on how their products work. The FDA, in turn, is responsible for protecting the public health and is for "helping the public get the accurate, science-based information they need to use medicines and foods to improve their health." This is right from their mission statement.&lt;/p&gt;&lt;p style="line-height: 1.6em"&gt;So all we need to do is enable the experts in the industry to share their knowledge with patients and providers to accelerate how the public receives accurate, science-based information. Right?&lt;/p&gt;&lt;p style="line-height: 1.6em"&gt;It sounds easy, but that's where the fun starts.&lt;/p&gt;&lt;p style="line-height: 1.6em"&gt;In a regulated industry, there is always a desire to "control" what is said. In the online world, customers couldn't care less. They want to get information quickly. The absence of experts in an online conversation does not prevent learning from occurring. It may not be accurate information, yet the "learning" continues unabated.&lt;/p&gt;&lt;p style="line-height: 1.6em"&gt;The FDA's goal, in my view, should be to enable companies to have actual conversations with their customers to correct misinformation, share product knowledge and learn together. Patients, who increasingly look to their potentially uninformed peers to make decisions, will be helped by hearing from experts, and providers will have 24/7 access to the best available content and thinking. This will require guidelines that are broad enough to allow conversations to occur, but comprehensive enough that a company is responsible for their overall contributions online.&lt;/p&gt;&lt;p style="line-height: 1.6em"&gt;I believe what each side wants from the guidelines is straight forward. Patients want to have conversations with fellow human beings at health companies and ask direct questions. They expect the industry to answer and become part of their conversations online in their favorite social media community. And, if possible, they would prefer to stay updated and ask questions via their smart phones and online resources. Healthcare providers want to hear the latest updates on the medicines or devices they offer to their patients. To facilitate this interaction, we need guidelines that respect the fact that a conversation unfolds over time. That means that while each exchange cannot be regulated, the overall effort can be. To do this, we need industry and social media experts to provide innovative solutions to the FDA. We then need the FDA to create guidelines that can evolve with the medium, rather than place increasing restrictions on it.&lt;/p&gt;&lt;p style="line-height: 1.6em"&gt;We all know it doesn't make sense to keep the experts (whether in companies or at the FDA) on the sidelines...ever. So why don't we open up the conversation, share information transparently and improve our collective knowledge to advance public health together?&lt;/p&gt;&lt;p style="line-height: 1.6em"&gt;This is not an easy task in a regulated environment. But patients and providers are counting on us.&lt;/p&gt;&lt;/span&gt;&lt;/span&gt;&lt;p&gt;By: &lt;em&gt;&lt;a href="http://blogs.harvardbusiness.org/cs/2009/11/whats_the_right_rx_for_social.html" target="_blank"&gt;Bob Pearson&lt;/a&gt;&lt;/em&gt; for &lt;a href="http://blogs.harvardbusiness.org/"&gt;Conversation Starter Blog&lt;/a&gt;.&lt;/p&gt;</crossTech:Body>
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               <dc:creator>Bob Pearson</dc:creator>
               <link>http://lifesciencesinsight.com/article.html?a=The-FDA,-Big-Pharma,-and-Social-Media:-What's-the-Right-Rx</link>
               <guid isPermaLink="false">http://lifesciencesinsight.com/article.html?a=The-FDA,-Big-Pharma,-and-Social-Media:-What's-the-Right-Rx/109cb981-30a4-4cf7-aee5-254b9cc9a3dd</guid>
               <pubDate>Tue, 08 Dec 2009 05:00:00 GMT</pubDate>
               <crossTech:date>12/8/2009</crossTech:date>
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               <title>Researcher seeks new treatments in old drugs</title>
               <description>From his outsider's vantage point, computer scientist Stephen Wong sees a big problem with drug discovery. It's too costly and too slow.&lt;br /&gt;&lt;br /&gt;And it's getting slower.</description>
               <crossTech:Body>&lt;span style="word-spacing: 0px; font-style: normal; font-variant: normal; font-weight: normal; font-size: medium; line-height: normal; font-size-adjust: none; font-stretch: normal; text-transform: none; text-indent: 0px; white-space: normal; letter-spacing: normal; border-collapse: separate; orphans: 2; widows: 2; font-family: 'times new roman'; color: rgb(0, 0, 0);" class="Apple-style-span"&gt;&lt;span style="text-align: left; font-family: arial,helvetica,sans-serif; font-size: 13px;" class="Apple-style-span"&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2444307" class="Text-TextBody HoustonText"&gt;&lt;span&gt;From his outsider's vantage point, computer scientist Stephen Wong sees a big problem with drug discovery. It's too costly and too slow.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2444312" class="Text-TextBody HoustonText"&gt;&lt;span&gt;And it's getting slower.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2444315" class="Text-TextBody HoustonText"&gt;&lt;span&gt;In 1998, the U.S. Food and Drug Administration approved 147 new drugs. Last year, just 11 new medicines were approved, continuing a downward trend even as drug companies and the federal government spend more money than ever on research and development.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2444322" class="Text-TextBody HoustonText"&gt;&lt;span&gt;Cost is one issue - by some estimates it runs half a billion dollars or more to bring a drug from the laboratory into the clinic. But there's another, underappreciated piece of the puzzle, said Wong, director of the Center for Biotechnology and Informatics at The Methodist Hospital Research Institute: Scientists may be running out of new biological targets inside the body, having already designed drugs to hit most of them.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2444325" class="Text-TextBody HoustonText"&gt;&lt;span&gt;If that's the case, Wong has a solution - finding new uses for the more than 1,000 FDA-approved drugs already on the market.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2437432" class="Text-TextBody HoustonText"&gt;&lt;span&gt;Many drugs have multiple impacts inside the body, hence the need to list possible side effects on drug labels. What's not clear for nearly all drugs is whether any of these secondary effects might be beneficial in treating other ailments, such as a hypertension medication that might also be effective at treating a rare form of cancer.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2437440" class="Text-TextBody HoustonText"&gt;&lt;span&gt;Wong believes he can use his computer skills - Methodist recruited him from Harvard University in 2007 - in the field of bioinformatics to identify new uses for old drugs.&lt;/span&gt;&lt;/p&gt;&lt;h3 style="border-width: 0px; margin: 0px 0px 3px; padding: 0px; font-family: arial; font-style: normal; font-variant: normal; font-weight: bold; font-size: 15px; line-height: normal; font-size-adjust: none; font-stretch: normal; outline-width: 0px;" id="id2443963" class="Text-TextSubhed BoldCond PoynterAgateZero"&gt;&lt;span&gt;Mining the data&lt;/span&gt;&lt;/h3&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2443989" class="Text-TextBody HoustonText"&gt;&lt;span&gt;The effort dates back about a decade, when it became affordable to store large amounts of information digitally and scientists began sequencing the human genome. Since then, biomedical researchers have performed thousands of genetic analyses of various diseases to determine which gene mutations contribute to the development of illnesses.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2443997" class="Text-TextBody HoustonText"&gt;&lt;span&gt;Nearly all of these terabytes of data are available in online databases accessible to scientists.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2444001" class="Text-TextBody HoustonText"&gt;&lt;span&gt;Additionally, the federal government required the results of publicly and privately funded clinical trials of experimental drugs to be published in a large online registry beginning in 1997, and ClinicalTrials.gov now contains 81,353 trials.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2439929" class="Text-TextBody HoustonText"&gt;&lt;span&gt;By mining the genetic data and the clinical trial database, using mathematical modeling and computer analysis, Wong believes he can match existing drugs with new diseases.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2439934" class="Text-TextBody HoustonText"&gt;&lt;span&gt;"This would not have been possible 20 or even 10 years ago," he said. "But now, with the very limited number of targets available for new drug development in complex diseases, we need a new approach."&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2439940" class="Text-TextBody HoustonText"&gt;&lt;span&gt;If Wong's method works, it is attractive for a couple of reasons. It not only puts expensive taxpayer-funded databases to good use, but also could bring the therapy to market much more quickly by taking advantage of familiar products.&lt;/span&gt;&lt;/p&gt;&lt;h3 style="border-width: 0px; margin: 0px 0px 3px; padding: 0px; font-family: arial; font-style: normal; font-variant: normal; font-weight: bold; font-size: 15px; line-height: normal; font-size-adjust: none; font-stretch: normal; outline-width: 0px;" id="id2439970" class="Text-TextSubhed BoldCond PoynterAgateZero"&gt;&lt;span&gt;Attacking cancer&lt;/span&gt;&lt;/h3&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2445986" class="Text-TextBody HoustonText"&gt;&lt;span&gt;A few years ago he began working with Dr. Jenny Chang, medical director of the Lester and Sue Smith Breast Center at Baylor College of Medicine.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2445991" class="Text-TextBody HoustonText"&gt;&lt;span&gt;Chang had performed a number of biopsies on breast cancer patients, both on those whose cancers were confined to the breast and on those whose cancers had metastasized to the brain.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2445997" class="Text-TextBody HoustonText"&gt;&lt;span&gt;Once breast cancer spreads to the brain, a patient's prognosis is generally less than a year, and there's no cure.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2446001" class="Text-TextBody HoustonText"&gt;&lt;span&gt;From those biopsies, Chang said she had identified a number of genetic pathways - ways in which gene mutations affected the ability of the cancer to spread - unique to patients who developed metastatic breast cancer.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2446011" class="Text-TextBody HoustonText"&gt;&lt;span&gt;"But I had a lot of trouble with the data and trying to translate it into clinical practice," she said. She couldn't find her way out from beneath the avalanche of data.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2446017" class="Text-TextBody HoustonText"&gt;&lt;span&gt;So she turned to Wong.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2446020" class="Text-TextBody HoustonText"&gt;&lt;span&gt;Using his mathematical modeling, Wong sifted through Chang's data and the large databases of genome and clinical trial data. Out of that, he identified several candidate drugs to impair the genetic pathways that helped the cancer spread.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2446026" class="Text-TextBody HoustonText"&gt;&lt;span&gt;One of them, a drug named sunitinib, which treats a kidney cancer called renal cell carcinoma, emerged as the best bet. Chang then tested the drug in mice, and the study showed it prevented breast cancer from spreading to the brain.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2434048" class="Text-TextBody HoustonText"&gt;&lt;span&gt;She has already begun a Phase II clinical trial of the drug, enrolling nine patients with metastatic breast cancer, and she is looking for more.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2434053" class="Text-TextBody HoustonText"&gt;&lt;span&gt;"The drug is very well- tolerated by patients, and so far the trial is going very well," Chang said.&lt;/span&gt;&lt;/p&gt;&lt;h3 style="border-width: 0px; margin: 0px 0px 3px; padding: 0px; font-family: arial; font-style: normal; font-variant: normal; font-weight: bold; font-size: 15px; line-height: normal; font-size-adjust: none; font-stretch: normal; outline-width: 0px;" id="id2434080" class="Text-TextSubhed BoldCond PoynterAgateZero"&gt;&lt;span&gt;Skipping Phase I&lt;/span&gt;&lt;/h3&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2434105" class="Text-TextBody HoustonText"&gt;&lt;span&gt;And therein lies the greatest advantage of using old drugs to perform new tricks: speed. It normally takes about a decade to go through all three phases of the FDA's clinical trial process.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2434413" class="Text-TextBody HoustonText"&gt;&lt;span&gt;But by using an existing drug, Chang and Wong could skip the lengthy Phase I, during which a drug is checked for safety. If Chang's tests go well, sunitinib could be on the market within a few years for metastatic breast cancer.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2434420" class="Text-TextBody HoustonText"&gt;&lt;span&gt;Wong said his computer-based approach may also prove useful in identifying not just single drugs, but the best forms of combination therapy. He said the potential of computers to transform biology is nearly limitless.&lt;/span&gt;&lt;/p&gt;&lt;p style="border-width: 0px; margin: 0px; padding: 0px 0px 7px; outline-width: 0px;" id="id2434426" class="Text-TextBody HoustonText"&gt;&lt;span&gt;"I predict that at some point during this century, half of the 'biologists' working in biology will not be biologists at all," he said.&lt;/span&gt;&lt;/p&gt;&lt;/span&gt;&lt;/span&gt;&lt;p&gt;By: &lt;em&gt;&lt;a target="_blank" href="http://www.chron.com/disp/story.mpl/metropolitan/6738041.html"&gt;Eric Berger&lt;/a&gt;&lt;/em&gt; for &lt;a href="http://www.chron.com/"&gt;&lt;img border="0" src="http://images.chron.com/photos/2009/06/10/new-chron-green/new-chron-green.gif" alt="Tech Watch" /&gt;&lt;/a&gt;.&lt;/p&gt;</crossTech:Body>
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               <dc:creator>Eric Berger</dc:creator>
               <link>http://lifesciencesinsight.com/article.html?a=Researcher-seeks-new-treatments-in-old-drugs</link>
               <guid isPermaLink="false">http://lifesciencesinsight.com/article.html?a=Researcher-seeks-new-treatments-in-old-drugs/aa467763-ab54-4dd9-8537-9b500c99a450</guid>
               <pubDate>Tue, 08 Dec 2009 05:00:00 GMT</pubDate>
               <crossTech:date>12/8/2009</crossTech:date>
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               <title>Most health IT firms still waiting for stimulus funds</title>
               <description>When President Obama's $19 billion electronic health records initiative was announced in February, as part of the American Recovery and Reinvestment Act, Paul Grabscheid, vice president of strategic planning of Intersystems Corp. said the company planned to hire 100 workers as a direct result of the economic stimulus funds. Today, the company has met that promise, and then some - adding between 150 and 200 workers by the end of this year, to its initial 800-person team.</description>
               <crossTech:Body>&lt;span style="word-spacing: 0px; font-style: normal; font-variant: normal; font-weight: normal; font-size: medium; line-height: normal; font-size-adjust: none; font-stretch: normal; text-transform: none; text-indent: 0px; white-space: normal; letter-spacing: normal; border-collapse: separate; orphans: 2; widows: 2; font-family: 'times new roman'; color: rgb(0, 0, 0);" class="Apple-style-span"&gt;&lt;span style="font-size: 12px; font-family: verdana,arial,helvetica,sans-serif; color: rgb(51, 51, 51);" class="Apple-style-span"&gt;&lt;p style="margin-top: 0px; line-height: 18px;"&gt;&lt;span&gt;When President Obama's $19 billion electronic health records initiative was announced in February, as part of the American Recovery and Reinvestment Act, Paul Grabscheid, vice president of strategic planning of Intersystems Corp. said the company planned to hire 100 workers as a direct result of the economic stimulus funds. Today, the company has met that promise, and then some - adding between 150 and 200 workers by the end of this year, to its initial 800-person team.&lt;br /&gt;&lt;br /&gt;But Grabscheid said that the stimulus package hasn't been the driver of that growth.&lt;/span&gt;&lt;/p&gt;&lt;p style="margin-top: 0px; line-height: 18px;"&gt;&lt;span&gt;In fact, much of Intersystems' new business has come from outside the United States. Projects in Chile and Europe have moved forward quickly, he said, in part because those countries have national health care with centralized information systems, rather than the fractured, complex patchwork we have here.&lt;br /&gt;&lt;br /&gt;Grabscheid said that the "stimulus effect" has been slow to materialize. "Inside the U.S., what we've seen is a lot of interest and activity and pent-up demand, " Grabscheid said. The ARRA does not begin offering incentives to doctors and hospitals to implement electronic medical records until 2011, and providers are waiting for guidance on so-called "meaningful use" rules, which are expected to be finalized next month.&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;The rules will tell providers what they need to do in order to be considered in compliance with "meaningful use" of electronic medical records, which will determine eligibility for reimbursement incentives from government health programs. These incentive payments begin in 2011 and gradually decrease. Starting in 2015, providers are expected to have adopted and be actively using a certified electronic health record, or EHR, that complies with the "meaningful use" definition or they will be subject to financial penalties under Medicare.&lt;br /&gt;&lt;br /&gt;"To some extent the stimulus is having the opposite effect," said Arthur Young, CEO at Natick-based Interbit Data Inc. "Customers are holding back from buying products, while they wait to hear the final guidelines." Young said his company has done some new targeted marketing of its products, to help reassure providers that the applications will conform to the "meaningful use" rules. Interbit's products are designed to help hospitals reach interoperability goals by translating health data from many different sources into one common language, a type of technological Esperanto called HL7.&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;The company partners with Westwood-based Meditech Inc. to provide complementary products and counts Cape Cod Hospital, and Newton-Wellesley Hospital among its customers. Young said he expects the company's revenue for 2009 to be $2.5 million, up from $2.1 million in 2008. But he expects business to ramp up in the coming months after the final guidelines are released. Interbit is also looking at introducing new products to capture some of this opportunity next year.&lt;br /&gt;&lt;br /&gt;Andover-based Sentillion Inc. is one company that is starting to feel the benefits of the legislation. One of the company's products provides doctors with single sign-on access to all of the different electronic medical records applications, whether it's for the laboratory or the radiology department.&lt;br /&gt;&lt;br /&gt;"Doctors have to access different applications up to 60 times per day. Imagine how much time it takes if they have to constantly enter new passwords," company president Paul Roscoe said. Sentillion has been growing slowly. But he plans to add 25 to 30 employees in 2010. The company will roll out new versions of products that include functions that will increase their "meaningful use" quotient.&lt;br /&gt;Sentillion also is seeing growth in sales of its Privacy Auditor. Roscoe believes this is because of the requirement, set to go into effect in September, that hospitals alert a patient within 60 days if his or her electronic health records have been breached.&lt;br /&gt;&lt;br /&gt;One company that has seen the dam burst is Wakefield-based Picis Inc., which provides electronic medical records for acute-care areas, including emergency and intensive-care units.&lt;br /&gt;&lt;br /&gt;CEO Todd Cozzens said that until the third quarter of 2009, his company was seeing the same kind of pent-up demand as other firms. "Since then we've had a tremendous surge," he said. "Our order book is filling up."&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;Picis has hired 80 employees this year, and plans to continue hiring in 2010. Cozzens expects to see growth of 10 percent to 15 percent next year. Cozzens said one factor in Picis' early success is that some of the company's products are specifically designed to help hospitals capture additional revenue, an attractive proposition during the recession.&lt;br /&gt;&lt;br /&gt;Other companies say they didn't expect an immediate boost from the stimulus, and that has been more important to get EHR implementation done right, rather than rush the process.&lt;br /&gt;&lt;br /&gt;Interbit's Young said he knows his time will come. "Every time there is a new regulation, it's a chance for us to make money," he said.&lt;/span&gt;&lt;/p&gt;&lt;/span&gt;&lt;/span&gt;&lt;p&gt;By: &lt;em&gt;&lt;a target="_blank" href="http://www.masshightech.com/stories/2009/11/30/weekly12-Most-health-IT-firms-still-waiting-for-stimulus-funds.html"&gt;Julie M. Donnelly&lt;/a&gt;&lt;/em&gt; for &lt;a href="http://www.masshightech.com/"&gt;Mass High Tech&lt;/a&gt;.&lt;/p&gt;</crossTech:Body>
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               <dc:creator>Julie M. Donnelly</dc:creator>
               <link>http://lifesciencesinsight.com/article.html?a=Most-health-IT-firms-still-waiting-for-stimulus-funds</link>
               <guid isPermaLink="false">http://lifesciencesinsight.com/article.html?a=Most-health-IT-firms-still-waiting-for-stimulus-funds/c388aaa2-db1b-465f-bf75-a34889919982</guid>
               <pubDate>Tue, 08 Dec 2009 05:00:00 GMT</pubDate>
               <crossTech:date>12/8/2009</crossTech:date>
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               <title>Eshoo bill huge boon for Silicon Valley biotech</title>
               <description>Buried in the giant health care bills in Congress is a multibillion-dollar bonanza for Silicon Valley's biotechnology and venture capital industries, sponsored by Rep. Anna Eshoo, a Palo Alto Democrat.</description>
               <crossTech:Body>&lt;span style="word-spacing: 0px; font-style: normal; font-variant: normal; font-weight: normal; font-size: medium; line-height: normal; font-size-adjust: none; font-stretch: normal; text-transform: none; text-indent: 0px; white-space: normal; letter-spacing: normal; border-collapse: separate; orphans: 2; widows: 2; font-family: 'times new roman'; color: rgb(0, 0, 0);" class="Apple-style-span"&gt;&lt;span style="text-align: left; font-size: 13px;" class="Apple-style-span"&gt;&lt;div id="bodytext_top" class="bodytext bodytext_top"&gt;&lt;div style="font-size: 1.25em; font-family: georgia,'times new roman',times,serif;" id="fontprefs_top" class="georgia md"&gt;&lt;p&gt;&lt;span&gt;Buried in the giant health care bills in Congress is a multibillion-dollar bonanza for Silicon Valley's biotechnology and venture capital industries, sponsored by Rep. Anna Eshoo, a Palo Alto Democrat.&lt;/span&gt;&lt;/p&gt;&lt;/div&gt;&lt;/div&gt;&lt;div style="clear: both;" class="clear"&gt;&lt;/div&gt;&lt;div id="bodytext_bottom" class="bodytext bodytext_bottom"&gt;&lt;div style="font-size: 1.25em; font-family: georgia,'times new roman',times,serif;" id="fontprefs_bottom" class="georgia md"&gt;&lt;p&gt;&lt;span&gt;The provision would grant "biologic" drugs, a new class of drugs based on gene splicing and grown in living cells, 12 years of protection from competition by the generic drug industry, in addition to their patents.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;A scathing report by the Federal Trade Commission in June said no added protection, much less 12 years, was warranted, and warned that the Eshoo legislation would ensure sky-high drug prices and stifle innovation on the most promising frontier of medical research.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;Eshoo, who has engaged in an angry public debate with patients in the blogosphere, argued that she is opening the door to cheaper "biosimilar" alternatives, not closing it, because no path to market such drugs currently exists.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;She crafted the legislation, she said, "with the highest purposes of bringing life-saving biologics to include biosimilars, to save lives and to bring down the costs to every human being in our country who needs them."&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;An article last month in the New England Journal of Medicine took issue with that claim, saying the Eshoo legislation creates the illusion of a path for cheaper substitutes that "would scarcely be used."&lt;/span&gt;&lt;/p&gt;&lt;h3 class="subhead"&gt;&lt;span&gt;Risks of gains, losses high&lt;/span&gt;&lt;/h3&gt;&lt;p&gt;&lt;span&gt;The stakes could hardly be higher for taxpayers, patients and the industry. With a $112 billion market now, biologics are expected to match within just a few years chemical pharmaceuticals for their share of new drug approvals by the Food and Drug Administration.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;The promise such medicines hold is breathtaking: Chemical drugs treat the symptoms of diseases while biologics, vastly more complex, focus on their genetic source.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;Many scientists believe that the most debilitating and dreaded diseases of modern life - cancer, AIDS, Parkinson's, multiple sclerosis, rheumatoid arthritis, Crohn's disease and many others - may one day see miracle breakthrough therapies, even cures, thanks to biologic drugs.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;Those drugs also tend to be very expensive. Herceptin, for treating breast cancer, can cost a patient more than $37,000 a year. Epogen, to treat anemia caused by renal failure, more than $84,000; Avastin, a lung cancer drug, $100,000; and Cerezyme, to treat Gaucher's disease, more than $200,000.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;Greg Bonaparte, 62, a construction manager who lives in Pescadero, has used biologic drugs to treat rheumatoid arthritis since the mid-1990s, paying as much as $1,100 every two months in co-pays for Remicade.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;He recently switched to another drug, Humira, because the drugmaker offers a program that covers almost all the drug's costs.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;"I can understand where the drug companies are coming from because they've put a lot of time and money into developing these things and they're fabulous drugs," he said, "but I'd love to see them go generic. I've been very fortunate because I've had jobs and money to pay for them but a lot of people can't."&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;The drugs can cost hundreds of millions of dollars to develop and are often financed by venture capital firms that expect a big payoff for the high risk. A blockbuster can yield billions of dollars in sales, but many never pan out.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;California is home to more than 2,000 biomedical companies, according to the California Healthcare Institute, an industry group. Public biomedical companies doing business in California spent more than $28 billion in research and development in 2007.&lt;/span&gt;&lt;/p&gt;&lt;h3 class="subhead"&gt;&lt;span&gt;Taxpayers heavily invested&lt;/span&gt;&lt;/h3&gt;&lt;p&gt;&lt;span&gt;Taxpayers have a big stake, too. Much of the basic research underlying biologics is financed by the National Institutes of Health. The government also pays for biologics through Medicare and Medicaid, spending an estimated $2 billion a year on Epogen alone, roughly equal to the budget of the Food and Drug Administration.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;The biotech industry spent $110 million- or $609,000 a day - lobbying Capitol Hill during the first six months of this year, according to figures compiled by Time Magazine, which counted 2.3 registered drug industry lobbyists for each member of Congress. The New York Times found dozens of Republicans and Democrats were inserting verbatim biotech industry talking points into the Congressional Record.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;With bipartisan support, Eshoo overpowered the chairman of the House Energy and Commerce Committee, Rep. Henry Waxman of Los Angeles, to get her legislation into the health care bill.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;Waxman wrote the first generic drug bill in 1984 with Utah Republican Sen. Orrin Hatch that opened chemical pharmaceuticals to competition from generics. Biologics were in their infancy then so they were left out of the law.&lt;/span&gt;&lt;/p&gt;&lt;h3 class="subhead"&gt;&lt;span&gt;Waxman shocked&lt;/span&gt;&lt;/h3&gt;&lt;p&gt;&lt;span&gt;The savings shocked even Waxman: $734 billion to the health care system in the last decade alone, while spurring, not depressing, competition. Waxman fought for the same five-year shield for the biotech industry but lost to Eshoo 47-11 in his own committee.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;The Obama administration opposed the legislation but facing certain defeat, offered a "generous compromise" of seven years of protection. The industry rejected that. The Eshoo bill has powerful sponsors in the Senate, including Hatch.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;The Senate version was originally sponsored by the late Sen. Edward Kennedy, whose home state of Massachusetts has a big biotech industry that contributed heavily to Kennedy's pet causes.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;The pharmaceutical industry is Eshoo's second-leading campaign contributor after the computer industry, donating nearly $170,000 in the 2008 election cycle, according to OpenSecrets.org, the Web site of the nonpartisan Center for Responsive Politics.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;David Gollaher, president and chief executive of the California Healthcare Institute, expressed confidence the Eshoo provision would survive. A shorter period of protection from competition, he said, would "hugely damage the amount of investment that venture capital and biotech companies are devoting to biologics .... This, at the end of the day, is all about lowering prices on biologics."&lt;/span&gt;&lt;/p&gt;&lt;h3 class="subhead"&gt;&lt;span&gt;Surprise boost from Dems&lt;/span&gt;&lt;/h3&gt;&lt;p&gt;&lt;span&gt;The Federal Trade Commission found that the 12-year protection would encourage companies to modify existing drugs rather than invent new ones. The monstrous difficulties in copying biologic drugs, and a host of other barriers, make current patent protections adequate, the agency concluded.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;So great are the difficulties that competition from unbranded substitutes may cut prices no more than 10 to 30 percent, the agency said, far less than the 80 percent drop that generics brought to the chemical drug market. Eshoo's staff said the FTC took an overly simplistic approach to the industry.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;Kathleen Jaeger, president of the Generic Pharmaceutical Association and a fierce opponent of the Eshoo bill, said generic drugmakers her group represents have begun to switch their research efforts to branded drugs.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;"For ten years, Big Pharma had a lock on the Republicans," Jaeger said. "And now it's just so surprising that they are going to be doing just as well or better under this new administration. They've just made some really good new friends in the Democratic Party."&lt;/span&gt;&lt;/p&gt;&lt;/div&gt;&lt;/div&gt;&lt;/span&gt;&lt;/span&gt;&lt;p&gt;By: &lt;em&gt;&lt;a target="_blank" href="http://www.sfgate.com/cgi-bin/article.cgi?file=/c/a/2009/12/06/MNFQ1AV2C3.DTL"&gt;Carolyn Lochhead&lt;/a&gt;&lt;/em&gt; for &lt;a href="http://www.sfgate.com/"&gt;&lt;img border="0" src="http://imgs.sfgate.com/chronicle/graphics/new/chronbanner.gif" alt="Tech Watch" /&gt;&lt;/a&gt;.&lt;/p&gt;</crossTech:Body>
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               <dc:creator>Carolyn Lochhead</dc:creator>
               <link>http://lifesciencesinsight.com/article.html?a=Eshoo-bill-huge-boon-for-Silicon-Valley-biotech</link>
               <guid isPermaLink="false">http://lifesciencesinsight.com/article.html?a=Eshoo-bill-huge-boon-for-Silicon-Valley-biotech/e59af2cf-1b83-4a2d-bf2b-b0e051aeaa85</guid>
               <pubDate>Tue, 08 Dec 2009 05:00:00 GMT</pubDate>
               <crossTech:date>12/8/2009</crossTech:date>
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               <title>Sermo Changes Strategy to Gain More Pharma Business, CEO Declines to Discuss Layoff Talk</title>
               <description>Sermo, provider of the nation's largest online community of doctors, has had a tough year in getting financial services firms to pay for access to its physician network and has decided to shift its strategy more toward serving drug and medical devices manufacturers, CEO Daniel Palestrant tells Xconomy. The change comes amid talk of layoffs circulating at Cambridge, MA-based Sermo, according to a source familiar with the matter.</description>
               <crossTech:Body>&lt;span style="word-spacing: 0px; font-style: normal; font-variant: normal; font-weight: normal; font-size: medium; line-height: normal; font-size-adjust: none; font-stretch: normal; text-transform: none; text-indent: 0px; white-space: normal; letter-spacing: normal; border-collapse: separate; orphans: 2; widows: 2; font-family: 'times new roman'; color: rgb(0, 0, 0);" class="Apple-style-span"&gt;&lt;span style="line-height: 16px; text-align: left; font-family: arial,sans-serif; font-size: 13px;" class="Apple-style-span"&gt;&lt;p&gt;&lt;span&gt;&lt;a onclick="window.open(this.href); javascript:pageTracker._trackPageview('/outgoing/www.sermo.com/'); return false;" style="color: rgb(0, 66, 118); text-decoration: none;" class="external" href="http://www.sermo.com/"&gt;Sermo&lt;/a&gt;, provider of the nation's largest online community of doctors, has had a tough year in getting financial services firms to pay for access to its physician network and has decided to shift its strategy more toward serving&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;a style="color: rgb(0, 66, 118); text-decoration: none;" href="http://www.xconomy.com/boston/2007/10/14/sermo-bags-a-big-pharma-fish/"&gt;drug and medical devices manufacturers&lt;/a&gt;, CEO Daniel Palestrant tells Xconomy. The change comes amid talk of layoffs circulating at Cambridge, MA-based Sermo, according to a source familiar with the matter.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;Xconomy has learned, from a source who asked to remain anonymous, that Sermo could be letting go more than one-third of its staff as soon as this week. Palestrant would neither confirm nor deny the possibility of layoffs, or say how many workers the firm employs. He did say, however, that Sermo has had to adjust its plan because the company has been affected by turmoil in the financial services sector and widespread consolidation and staff reductions in the pharmaceutical industry.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;"We have to look at ourselves less as a startup company and more as an operating company," Palestrant said. "That has all sorts of ramifications in the kinds of people you leverage, making cash flow-positive and profitability a tremendous priority." He noted that Sermo is doing better than many other Web startups focused on health care-or so-called Health 2.0 firms-some of which have either folded or have been consolidated.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;Sermo, which has raised more than $39 million in venture capital since its founding in 2005, allows physicians to circulate questions among their peers about how to best diagnose and treat patients with certain symptoms. The insights from this professional social networking are thought to be valuable not just for the physicians themselves, but for investors and drug companies that want to better understand how physicians use certain medical technologies. Sermo aims to sell subscriptions to those clients who want access to its database, but evidently, Wall Street wasn't in a position to widely adopt this new tool for research this year.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;Sermo's online community has grown to more than 110,000 physicians. Last year, Sermo vastly expanded the access of financial analysts to its physicians-only community with the firm's highly publicized partnership with New York-based financial information giant Bloomberg LP. Palestrant said the Bloomberg partnership remains intact, but he declined to provide details on whether it's been a moneymaker for the company.&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;a style="color: rgb(0, 66, 118); text-decoration: none;" href="http://www.xconomy.com/boston/2008/10/23/bloomberg-subscribers-get-access-to-sermo-physician-forum/"&gt;The deal was struck in October 2008&lt;/a&gt;, a month after the collapse of Lehman Brothers and meltdown of other financial services firms.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;"2009 is a lost year for financial services," Palestrant says. "We've really tried to service our existing financial services clients while focusing on where the lion's share of our revenue comes from, which is pharma."&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;The growth of the company's community of doctors appears to have slowed in 2009 as well. Based on figures from Sermo, the community grew from 50,000 to 90,000 physicians in 2008. The firm says that its community has added about 20,000 more physicians this year. Palestrant said, however, that activation among community members has grown by about 50 percent this year, but he didn't provide specifics on how the company defines this measurement, or how active all of the physicians are. He noted Sermo has made a major push to improve the user experience with a next-generation Web platform, into which the firm has put 85 percent of its engineering efforts this year and plans to launch in 2010.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;On the financing front, Palestrant says that his company has money to meet its future needs. There are plenty of investors that want to back his firm, Palestrant says, but he would not comment on whether the firm plans to raise another round of venture capital. Sermo board member Paul Margolis, a partner at Waltham, MA-based Longworth Venture Partners, told me last week that his firm would continue to fund the startup if it raises more money. He deferred all comments on Sermo's finances to Palestrant.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;Sermo raised $39.2 million in venture capital through three rounds of financing from September 2006 to September 2007, according to the firm's website. The company's investors include Longworth, Softbank Capital, and Legg Mason Capital Management.&lt;/span&gt;&lt;/p&gt;&lt;/span&gt;&lt;/span&gt;&lt;p&gt;By: &lt;em&gt;&lt;a target="_blank" href="http://www.xconomy.com/boston/2009/12/07/sermo-changes-strategy-to-gain-more-pharma-business-ceo-declines-to-discuss-layoff-talk/?single_page=true"&gt;Ryan McBride&lt;/a&gt;&lt;/em&gt; for &lt;a href="http://www.xconomy.com/"&gt;&lt;img border="0" src="http://www.xconomy.com/wordpress/wp-content/themes/xconomy/images/header_national.gif" alt="Tech Watch" /&gt;&lt;/a&gt;.&lt;/p&gt;</crossTech:Body>
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               <dc:creator>Ryan McBride</dc:creator>
               <link>http://lifesciencesinsight.com/article.html?a=Sermo-Changes-Strategy-to-Gain-More-Pharma-Business,-CEO-Declines-to-Discuss-Layoff-Talk</link>
               <guid isPermaLink="false">http://lifesciencesinsight.com/article.html?a=Sermo-Changes-Strategy-to-Gain-More-Pharma-Business,-CEO-Declines-to-Discuss-Layoff-Talk/884cf16a-d76f-4a1f-b631-a57a001b4bf4</guid>
               <pubDate>Tue, 08 Dec 2009 05:00:00 GMT</pubDate>
               <crossTech:date>12/8/2009</crossTech:date>
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               <title>Wikis to open drug development sharing</title>
               <description>Taking the open concept a step further is the Bioinformatics Organization, an open source practitioner that uses wiki software to let researchers post their models, questions, experiments and discoveries.</description>
               <crossTech:Body>&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;Taking the open concept a step further is the Bioinformatics Organization, an open source practitioner that uses wiki software to let researchers post their models, questions, experiments and discoveries.&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;Bioinformatics President Jeff Bizarro says in&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;em&gt;LinuxInsider&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;/em&gt;that the organization was created to allow researchers in the same discipline to share information with their peers. It's a central location for open source projects, now 27,000 members strong. They use the wiki site to post projects involving, for example, DNA and RNA sequence analysis, protein analysis and drug discovery.&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;The Bioinformatics Internet site currently notes the release of BioPuppy 2.0, a minimal Linux operating system and workbench for bioinformatics and computational biology. Version 2.0 is based on the current Linux kernel version on Puppy Linux 4.2.1.&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;Note the disquieting&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;a href="http://www.bioinformatics.org/" style="text-decoration: none; color: rgb(42, 51, 132);"&gt;poll question&lt;/a&gt;&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;on the Bioinformatics home page: Could computer models someday replace humans in clinical trials?&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;- read the&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;em&gt;LinuxInsider&lt;/em&gt;&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;a href="http://www.linuxinsider.com/story/Open-Source-Science-A-Revolution-From-Within-68701.html?wlc=1258750878" style="text-decoration: none; color: rgb(42, 51, 132);"&gt;article&lt;/a&gt;&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;&lt;a href="http://www.linuxinsider.com/story/Open-Source-Science-A-Revolution-From-Within-68701.html?wlc=1258750878" style="text-decoration: none; color: rgb(42, 51, 132);"&gt;&lt;br /&gt;&lt;/a&gt;&lt;/p&gt;&lt;p&gt;By: &lt;em&gt;&lt;a target="_blank" href="http://www.fiercebiotechit.com/story/wikis-open-drug-development-sharing/2009-11-23"&gt;George Miller&lt;/a&gt;&lt;/em&gt; for &lt;a href="http://www.fiercebiotechit.com/"&gt;&lt;img border="0" src="http://www.fiercebiotechit.com/public/logos/fiercebiotechit245.gif" alt="Tech Watch" /&gt;&lt;/a&gt;.&lt;/p&gt;</crossTech:Body>
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               <dc:creator>George Miller</dc:creator>
               <link>http://lifesciencesinsight.com/article.html?a=Wikis-to-open-drug-development-sharing</link>
               <guid isPermaLink="false">http://lifesciencesinsight.com/article.html?a=Wikis-to-open-drug-development-sharing/92b676b1-4971-4a72-8a77-bda726d202a7</guid>
               <pubDate>Tue, 24 Nov 2009 05:00:00 GMT</pubDate>
               <crossTech:date>11/24/2009</crossTech:date>
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               <title>Pharma's Seek FDA Guidance on Social Media</title>
               <description>Pharmaceutical sales and marketing has become increasingly challenging over the last several years for a number of reasons. Rising patient loads resulting from the aging baby boomer generation have overloaded doctors, leaving little to no time for physicians to see pharmaceutical sales representatives. The average interaction time between a physician and sales rep is now less than 30 seconds in primary care settings. Industry regulations have gotten much stricter as well, creating numerous obstacles for pharma manufacturers.</description>
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               <dc:creator>Eric Newmark</dc:creator>
               <link>http://idc-insights-community.com/posts/149e9539a2</link>
               <guid isPermaLink="false">http://idc-insights-community.com/posts/149e9539a2/6f702489-3faa-405d-be0a-ec2945ac57a5</guid>
               <pubDate>Tue, 24 Nov 2009 05:00:00 GMT</pubDate>
               <crossTech:date>11/24/2009</crossTech:date>
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               <title>The 'C' Word</title>
               <description>By his own admission, BioTeam co-founder and technology director Chris Dagdigian is a cynical sort, dedicated to the productive use of IT resources, focused on results and cost-and pathologically averse to marketing spin. That makes his positive reception to cloud computing all the more compelling. Just don't call it "cloud computing."</description>
               <crossTech:Body>By his own admission, BioTeam co-founder and technology director Chris Dagdigian is a cynical sort, dedicated to the productive use of IT resources, focused on results and cost-and pathologically averse to marketing spin. That makes his positive reception to cloud computing all the more compelling. Just don't call it "cloud computing."&lt;br /&gt;&lt;br /&gt;Delivering a masterful overview of the cloud at the inaugural Bio-IT World Europe conference in October, Dagdigian confessed: "'Cloud computing' is to me exactly the word I hate, just like I hated 'Grid computing' in the '90s. The word itself has been perverted by way too many marketing organizations." Multi-site Grid computing was "98% hype and 2% usefulness," Dagdigian recalled. So why did Dagdigian "drink the Kool-Aid" over cloud computing?&lt;br /&gt;&lt;br /&gt;The tipping point came in late 2007. Dagdigian and his BioTeam colleagues realized that, without any managerial mandate, the whole group of consultants was independently experimenting with Amazon Web Services (AWS) to solve a customer problem. The cost of EC2 is ridiculously cheap, with almost infinite ways of controlling it.&lt;br /&gt;&lt;br /&gt;"It works because the pricing is smart," said Dagdigian. "Amazon blew people out of the water. Others were charging $1-2/hr. They disrupted the market by starting at 10 cents/hr." Experimenting was addictive and affordable. After a week of messing around, Dagdigian's first bill from Amazon was less than $10.&lt;br /&gt;&lt;br /&gt;While the pace of AWS development impresses even a cynic such as Dagdigian, the primary virtue of the cloud, he explains, boils down to this: "If you have a 100 CPU-hour research problem, you can fire up 10 servers and solve the problem in 10 hours for $40. Or fire up 100 servers and solve the problem in 1 hour for the same money. That's the 'Aha' moment."&lt;br /&gt;&lt;br /&gt;Dagdigian asked rhetorically: "Do you have that type of virtual scaling power in your facility? And if you do, how much of your infrastructure are you willing to keep idle and running so you can actually burst onto that scale?"&lt;br /&gt;&lt;br /&gt;Dagdigian tries hard not to use the term 'cloud,' preferring instead utility computing or simply "The C word."&lt;br /&gt;&lt;br /&gt;"Amazon Web Services is the cloud," said Dagdigian (see, "Amazon's Big Cloud"). "Anybody who tries to claim otherwise is fooling themselves or believes their own marketing. Amazon has a multiple year head start on everybody else. Google is probably not going to catch up. Microsoft is probably not going to catch up. They probably have six months to catch up, and if they don't do it in six months, [AWS] will rule the world."&lt;br /&gt;That could change, of course. The Googles and Microsofts of the world have the money, smart people, infrastructure, and there could be disruptive changes ahead. "But Amazon has been doing this long enough and they're improving their product rapidly enough, we're talking a multiyear head start."&lt;br /&gt;&lt;br /&gt;Not Rocket Science&lt;br /&gt;When Dagdigian talks about cloud computing, he says he's not talking about SaaS, or SalesForce.com, or magical cloud terms. "I'm talking about utility computing as it resonates with an infrastructure person-servers, systems, workflows, scientific application pipelines ... At the end of the day, I'm interested in replicating and duplicating complex systems."&lt;br /&gt;&lt;br /&gt;Cloud computing "really isn't rocket science," he says. Unlike Grid computing, Dagdigian says "it's actually very easy to get your head around. You'll know intuitively what parts of your research workflow make sense" to try in the cloud. The AWS tutorial takes less than half a day.&lt;br /&gt;&lt;br /&gt;But Dagdigian's assessment of 'private clouds' is blunt: "Absolute rubbish," he said, arguing the term is being slapped onto virtualization services in another marketing makeover.&lt;br /&gt;&lt;br /&gt;"There's a lot of people trying to sell you the vision of, 'Ooh, look at what you can do inside Amazon. You can do that inside your own datacenter. That's probably a really cool future a couple of years down the road, but right now it is people trying to get IPO/venture funding ... Nothing's been extensively tested. To build a private cloud in '09, you take your VMware stuff, all your virtualization stuff ... wave the magic marketing pixie dust, and excrete a press release. Give it a year."&lt;br /&gt;&lt;br /&gt;That said, Dagdigian admits there are some interesting academic pilot projects in private cloud computing going on, and it's "a great topic for a thesis." But one of the "inconvenient truths" of private clouds is that the ability to move systems internally to meet business and scientific needs requires re-architecting the network, and in his view it's not ready for prime time.&lt;br /&gt;&lt;br /&gt;Dagdigian ticked off four primary areas in which his company is already using the cloud:&lt;br /&gt;&lt;br /&gt;Part of BioTeam's own business, such as development software engineering, is done on the cloud;&lt;br /&gt;Training sessions for resources such as Grid Engine. The cloud enables everybody in the class to essentially get their own cluster, turning an expense of potentially thousands of dollars using a conventional cluster into a few dollars using AWS. "The most expensive bill for training was under $300," says Dagdigian, and that was because he forgot to shut down the machines overnight.&lt;br /&gt;Proof-of-concept projects for companies such as Sun and Univa.&lt;br /&gt;Directed efforts for ISVs porting applications, and some pharma clients doing real science such as molecular modeling (see, "Antibody Docking on the Amazon Cloud," BioIT World, May 2009).&lt;br /&gt;Amazon's cloud is much more than just EC2-it is a collection of discrete services available on demand that can be combined in interesting ways to build workflows. Dagdigian spoke enthusiastically about Amazon's rapid product development cycle and steady stream of new features, such as auto-scaling, Simple DB (for SQL-like queries), two storage products (one of which is Amazon's S3, or Simple Storage Service), and the simple queue system (SQS) to build pipelines and pass messages.&lt;br /&gt;&lt;br /&gt;Coping with the data tsunami today is more challenging than acquiring compute power to solve problems. AWS now has a physical ingest/outgest service. Dagdigian described how one can mail Amazon a SATA or USB disk, delivering data much faster than over the Internet. That should ensure there isn't a repeat of a "very nasty problem" Dagdigian faced earlier this year, when tasked with quickly moving 20 TB of data out of the Amazon cloud to be delivered to a client. "Amazon had no solution for bulk export," he said. It would be virtually impossible to lease very fast Internet connections for short periods. Fortunately, friends at 2NPlus1, a local datacenter, and an Ivy League university provided the bandwidth (ultimately a Gigabit Ethernet connection) to solve the problem.&lt;br /&gt;&lt;br /&gt;Overall, Dagdigian is enthusiastic about the cloud, but he freely admits there has been a "ridiculous amount of hype." He points potential users to a white paper by McKinsey that outlines the downsides to utility computing, which he calls a "fantastic read if you're very excited about cloud computing." It is also imperative for would-be users to have "a solid understanding of their own internal operating costs, ranging from servers, to electricity to buildings to administration. In many ways, utility computing is about economics and saving money. You must have a solid way of modeling your IT operations ... Unless you do that, you're probably going to lose a lot of money in the cloud."&lt;br /&gt;&lt;br /&gt;The question of cloud security is both "interesting and overblown," says Dagdigian. "There's absolutely a whiff of hypocrisy in the air," which he suggests comes from IT staff trying to protect their jobs. "It's very funny to see people demanding security practices on the cloud that they're unable to run in-house."&lt;br /&gt;&lt;br /&gt;Dagdigian argues that Amazon, Google, and Microsoft have better internal controls than any biotech, pharma, or academic IT manager. "They're not stupid. They've hired incredibly smart people ... They will answer every question you can throw at them." Moreover, Amazon allows users to implement their own security practices. "There's no technical barrier to having you encrypt every single packet that goes to and from the cloud." Amazon has published white papers on cloud security and HIPAA compliance.&lt;br /&gt;&lt;br /&gt;Dagdigian's colleague Adam Kraut worked with Pfizer to solve a molecular modeling workflow that typically required 48 hours on 72 CPUs. Shifting that work to the cloud, marshalling some 500 CPUs, could produce an answer within 3.5 hours (see p. 32). Dagdigian said that, "in many cases, protein docking is an ideal application for cloud computing."&lt;br /&gt;&lt;br /&gt;Cloud computing is not nirvana. One bottleneck for some is "the ingest problem," but if that can be solved, Dagdigian predicts "there's a possibility of petabyte-scale volumes of data moving into the cloud. They can post it and store it cheaper than I can do it safely and securely at home." Another interesting model is that of user downloads, where researchers funded by public grants could share multi-TB datasets and meet sharing requirements by asking the downloader to pay.&lt;br /&gt;&lt;br /&gt;"This is a very hyped and trendy area, and not a solution for everybody," said Dagdigian. Users need to find the middle ground between Luddites and evangelists. The bottom line: "Start small, stay targeted, and go for the easy stuff first." &lt;br /&gt;&lt;p&gt;By: &lt;em&gt;&lt;a href="http://www.bio-itworld.com/2009/11/18/c-word.html" target="_blank"&gt;Kevin Davies&lt;/a&gt;&lt;/em&gt; for &lt;a href="http://www.bio-itworld.com/"&gt;Bio-IT World&lt;/a&gt;.&lt;/p&gt;</crossTech:Body>
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               <dc:creator>Kevin Davies</dc:creator>
               <link>http://lifesciencesinsight.com/article.html?a=The-'C'-Word</link>
               <guid isPermaLink="false">http://lifesciencesinsight.com/article.html?a=The-'C'-Word/b66bd588-24ce-4a72-8f36-dc5ba5009b42</guid>
               <pubDate>Tue, 24 Nov 2009 05:00:00 GMT</pubDate>
               <crossTech:date>11/24/2009</crossTech:date>
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               <title>Cycle Computing's Tour de Cloud</title>
               <description>Despite the enormous appeal of cloud computing, making practical use of resources such as Amazon's EC2 is not straightforward. One key issue is scheduling. Jason Stowe, the founder and CEO of Cycle Computing, says that his firm's service, the CycleCloud, attempts to solve a very straightforward problem: "Amazon allows you to provision 1000 servers. Now what?... How do you make it so the submission you just did 5 minutes ago starts running sooner than the submission yesterday, because its higher priority?"</description>
               <crossTech:Body>Despite the enormous appeal of cloud computing, making practical use of resources such as Amazon's EC2 is not straightforward. One key issue is scheduling. Jason Stowe, the founder and CEO of Cycle Computing, says that his firm's service, the CycleCloud, attempts to solve a very straightforward problem: "Amazon allows you to provision 1000 servers. Now what?... How do you make it so the submission you just did 5 minutes ago starts running sooner than the submission yesterday, because its higher priority?"&lt;br /&gt;&lt;br /&gt;"With EC2, the math really changes," says Stowe. The cloud can dramatically accelerate the time result compared to a fixed cluster. "A task that used to take six weeks now takes less than a day. It's going to really affect a lot of industries, but life sciences is first, because you guys are generating a lot of data, and the ratio of computation to data is still very high. It's on a scale that works well on EC2."&lt;br /&gt;&lt;br /&gt;Amazon tries to help users, but as Stowe says, "they're not explicitly in the business of helping life sciences users provision computing resources to run them. They're in the business of providing infrastructure as a service." Scheduling that activity and helping people use the cloud infrastructure practically and securely is what Cycle offers.&lt;br /&gt;&lt;br /&gt;Cycle helps users take internal workflows and provision clusters for short-term needs. It also works with other software and instrument providers to offer HPC environments dynamically to customers that don't have the IT staff to manage them. "Pharma is very forward thinking on this," says Stowe. "They're definitely the first with their feet in the water, along with finance and maybe 1-2 other industries, such as Web 2.0."&lt;br /&gt;&lt;br /&gt;Math is different in the cloud. Stowe says 1000 compute hours costs the same whether its 1 CPU for 1000 hours or 1000 CPUs for 1 hr. "That cost differential is huge compared to the old model," he says. "I'd have to buy 1000 computers to get the 1-hour time to market. A lot of people couldn't afford to do that, especially on short notice. An old-school IT view would be: if your department was really moving, you could get a new computer in a month, or 4 months for a cluster (installed, racked, cabled, powered, storage, etc.) Now you can do that in 15 minutes-and it costs less!"&lt;p&gt;&lt;/p&gt;&lt;strong&gt;Early Start&lt;/strong&gt;&lt;br /&gt;Stowe trained in math and computer science and enrolled at Carnegie Mellon in 1993, a couple of years earlier than his class mates. He later transferred to Cornell and had a stint at Microsoft. His interests focused on algorithms for rendering, but his first company foundered in the 2001-02 dot com crash. But one of his customers later called up from Toronto, requesting rendering assistance for a movie. He spent a year working on the Disney film The Wild, running a supercomputer with 1250 processors in the top 100 list at the time.&lt;br /&gt;&lt;br /&gt;Stowe started Cycle in 2005 to help companies do HPC using Condor as an open-source scheduler (see, "Condor Rules"). "Everybody had the same problem," said Stowe. "For bursts of usage, they had to buy clusters for peak utilization, but then day-to-day wouldn't need the peak usage. When EC2 came out in 2006, we saw that as a way of solving that problem." Early clients included JP Morgan Chase and Lockheed Martin. Through a mixture of luck and hard work, Stowe built larger implementations, especially in financial services. And he got a credit on The Wild.&lt;br /&gt;&lt;br /&gt;In late 2007, Stowe won his first paying customers. Cycle's first life sciences client was Varian, a manufacturer of mass spectrometers. Cycle reduced an internal simulation from six weeks to under a day on EC2 just by "spinning it up." Stowe took the call on a Tuesday, and the calculation was done by Thursday: a classic demonstration of the virtues of Condor, the cloud, and Cycle.&lt;br /&gt;&lt;br /&gt;Cloud services is the fastest growing segment of Cycle's business, making up a third of Cycle's total business. A lot of people want both. "We implement Condor internally, which makes it easier to use it externally." Some of Cycle's pharma clients include Pfizer, Eli Lilly, and Johnson &amp;amp; Johnson (see p. 31). Stowe says there are two good reasons why life science companies have embraced cloud computing. &lt;br /&gt;&lt;br /&gt;One is outsourcing: pharma and the life sciences has been more comfortable with outsourcing IT and other technologies for a while, he says. "There's definitely more of a culture that we want to focus on science, not IT. Other industries view IT as proprietary."&lt;br /&gt;&lt;br /&gt;Second are some clear user cases. Users can perform runs every night, avoiding lengthy down times for empty clusters, or review years of old data with a new algorithm or technology. "Those data are going to sit there idle, or you can do it on EC2, have it down and you're done."&lt;p&gt;&lt;/p&gt;&lt;strong&gt;From A to Z&lt;/strong&gt;&lt;br /&gt;Amazon was years ahead of the field, says Stowe. "They're by far the easiest to use, easiest to start up, particularly if you're comfortable with programming. They also have a lot of vendors like us that make it easier to use the servers." But Stowe is looking at other vendors, including HP, vCloud, and IBM, who might at some point provide comparable or better infrastructure.&lt;br /&gt;&lt;br /&gt;Cycle offers clients a turnkey cluster in effect. "You want to spin up a cluster to run work, you don't need to know anything about virtual machine images," said Stowe. "We have folks to help with app migration for HPC work, we do training on Condor, training on clusters, 24/7 support. We offer a full range of services. Someone can very easily say, here's a proteomics workflow or assembly of genomes, I want to turn it on and dial it up."&lt;br /&gt;&lt;br /&gt;Stowe can't reveal much in the way of early customers, but he's attracting interest from academic research organizations. The Cycle model works well in the grant funding world, particularly when there isn't a major IT department. "With cloud computing, instead of a capital expenditure (and depreciation), you have an operating expenditure."&lt;br /&gt;&lt;br /&gt;Lilly has worked in genomics applications, including BLAST, pharmacokinetics using NONMEM, statistics analysis through R, as well as simulations of clinical trial data. Cycle has done chemical simulation work in molecular dynamics with Schrodinger, helping its scientists run calculations by ramping up large numbers of nodes in the cloud.&lt;br /&gt;&lt;br /&gt;Not surprisingly, Stowe sees opportunity in managing next-gen sequencing data. "We're looking at [next-gen] instrument providers by helping provide an on-demand cluster that spins up and has software provision," says Stowe. "Here, it would be running alignment and assembly calculations." Considerations would include where to grab the data, how to transfer it, and establishing the proper provisioning methodology. "How do we qualify these images, so if the FDA wants to know 18 months ago how this machine was generated, we have all that data, the qualification and audit? The cloud offers benefits of reproducibility and tracking."&lt;br /&gt;&lt;br /&gt;A next-gen run might generate 6 Terabytes image data, distilled down to 100 GB. "At that point," says Stowe, "it makes a lot of sense to parallelize and use the cloud to do computation. Plus, those 100 GB can be streamed potentially as the instrument is operating. So over the 7-day read, you can stream that data up, so it doesn't have huge bandwidth requirements." The first part of the sequence analysis would be done on the instrument, and cloud calculations could deliver the assembled genome. "Plug your Internet connection into [the sequencer], and stream it up to EC2, and there's no IT department required for a wet lab to be able to use the results."&lt;p&gt;&lt;/p&gt;&lt;p&gt;By: &lt;em&gt;&lt;a href="http://www.bio-itworld.com/2009/11/20/cycle.html" target="_blank"&gt;Kevin Davies&lt;/a&gt;&lt;/em&gt; for &lt;a href="http://www.bio-itworld.com/"&gt;Bio-IT World&lt;/a&gt;.&lt;/p&gt;</crossTech:Body>
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               <dc:creator>Kevin Davies</dc:creator>
               <link>http://lifesciencesinsight.com/article.html?a=Cycle-Computing's-Tour-de-Cloud</link>
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               <pubDate>Tue, 24 Nov 2009 05:00:00 GMT</pubDate>
               <crossTech:date>11/24/2009</crossTech:date>
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               <title>Britons and Americans turning thumbs down on H1N1 vax</title>
               <description>With one segment of British society fearful of the potential side effects of a new swine flu vaccine and another large group shrugging off the pandemic as much ado about nothing, more than half of the island's population is saying no to the shot. And it's not solely a British phenomenon. A new poll from CNN/Opinion Research reveals that 55 percent of American adults will shun the vaccine.</description>
               <crossTech:Body>&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;With one segment of British society fearful of the potential side effects of a new swine flu vaccine and another large group shrugging off the pandemic as much ado about nothing, more than half of the island's population is saying no to the shot. And it's not solely a British phenomenon. A new poll from CNN/Opinion Research reveals that&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" href="http://www.cnn.com/2009/HEALTH/11/18/poll.h1n1.vaccine/index.html"&gt;55 percent of American adults will shun the vaccine&lt;/a&gt;.&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;Doctors surveyed by&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;em&gt;Pulse&lt;/em&gt;&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;magazine in the UK say that pregnant women are among the hardest to persuade to get vaccinated, even though they are among the most vulnerable to the H1N1 virus. "In all the pregnant women we've offered it to, I think only about one in 20 has agreed," said Dr. Chris Udenze, a family doctor.&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;While swine flu has killed more than 7,000 people worldwide, the UK's earlier estimates concerning the possible spread of the virus have had to be scaled down twice. Those revisions have only enhanced skepticism among many that swine flu is something to be afraid of. At the very least, a large number of people seem more scared of the vaccine than they are of the virus.&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;Epidemiologists have been learning plenty about the way the world greets a pandemic. Of key concern are the huge numbers of people who refuse to get vaccinated. Without widespread use, society loses the herd protection that can be afforded the occasional naysayer. But if more than half of the population bows out, a more lethal virus would do far more damage. Luckily, swine flu is typically quite mild, making the current pandemic a dry run for future outbreaks. Not all the lessons learned are comforting.&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;- here's the&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" href="http://www.reuters.com/article/healthNews/idUSTRE5AH25620091118"&gt;story&lt;/a&gt;&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;from&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;em&gt;Reuters&lt;/em&gt;&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;&lt;strong&gt;Related Articles:&lt;br /&gt;&lt;/strong&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" href="http://www.fiercevaccines.com/story/fast-spreading-flu-may-have-infected-millions/2009-10-29"&gt;Fast-spreading flu may have infected millions&lt;/a&gt;&lt;br /&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" href="http://www.fiercevaccines.com/story/vax-will-likely-trigger-tsunami-adverse-event-claims/2009-09-17"&gt;Vax will likely trigger tsunami of adverse event claims&lt;/a&gt;&lt;br /&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" href="http://www.fiercevaccines.com/story/side-effect-fears-spur-docs-reject-swine-flu-vax/2009-08-26"&gt;Side effect fears spur docs to reject swine flu vax&lt;/a&gt;&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" href="http://www.fiercevaccines.com/story/side-effect-fears-spur-docs-reject-swine-flu-vax/2009-08-26"&gt;&lt;br /&gt;&lt;/a&gt;&lt;/p&gt;&lt;p&gt;By: &lt;em&gt;&lt;a href="http://www.fiercevaccines.com/story/britons-turning-thumbs-down-h1n1-vax/2009-11-18" target="_blank"&gt;John Carroll&lt;/a&gt;&lt;/em&gt; for &lt;a href="http://www.fiercevaccines.com/"&gt;&lt;img border="0" alt="Fierce Vaccines" src="http://www.fiercevaccines.com/images/fiercevaccines.gif" /&gt;&lt;/a&gt;.&lt;/p&gt;</crossTech:Body>
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               <dc:creator>John Carroll</dc:creator>
               <link>http://lifesciencesinsight.com/article.html?a=Britons-and-Americans-turning-thumbs-down-on-H1N1-vax</link>
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               <pubDate>Tue, 24 Nov 2009 05:00:00 GMT</pubDate>
               <crossTech:date>11/24/2009</crossTech:date>
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               <title>Life Science RFID Utilization Declines</title>
               <description>When we last checked in on RFID adoption back in January 2009, evaluations and adoption rates had still been increasing, continuing a 24 month trend of increasing interest in the technology. While adoption rates were still far from widespread, and nowhere near mainstream levels that many had predicted would occur during the early part of this decade, upward trends were still progressing. Approximately 43% of companies were assessing the technology (doubling from just 21% of companies conducting evaluations a year earlier during the beginning of 2008).</description>
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               <dc:creator>Eric Newmark</dc:creator>
               <link>http://idc-insights-community.com/posts/dcbbf5e3c9</link>
               <guid isPermaLink="false">http://idc-insights-community.com/posts/dcbbf5e3c9/770ece42-2ba3-488f-bf87-c0ab03e434ed</guid>
               <pubDate>Mon, 09 Nov 2009 05:00:00 GMT</pubDate>
               <crossTech:date>11/9/2009</crossTech:date>
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               <title>Big Pharma maps out a global vaccine strategy</title>
               <description>Novartis' announcement earlier this week that it is snapping up an 85 percent interest in China's Zhejiang Tianyuan Bio-Pharmaceutical Company underscores Big Pharma's appetite for a big slice of the growing worldwide market for vaccines. As the Wall Street Journal notes, this is just the most recent in a string of such deals, which includes Sanofi's move last summer to acquire Shantha Biotechnics, a big player in India and the rest of the developing world.</description>
               <crossTech:Body>&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;Novartis' announcement earlier this week that it is snapping up an 85 percent interest in China's Zhejiang Tianyuan Bio-Pharmaceutical Company underscores Big Pharma's appetite for a big slice of the growing worldwide market for vaccines. As the&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;em&gt;Wall Street Journal&lt;/em&gt;&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;notes, this is just the most recent in a string of such deals, which includes&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" href="http://www.fiercebiotech.com/story/sanofi-snaps-indias-shantha-784m/2009-07-27"&gt;Sanofi's move last summer to acquire&amp;nbsp;Shantha Biotechnics&lt;/a&gt;, a big player in India and the rest of the developing world.&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;While the vaccine makers have been reaping a bumper crop of multibillion-dollar sales to wealthy countries like the U.S., it's emerging markets like China and India that will offer much of the future demand for vaccines. As these countries grow more affluent, their governments are becoming more ambitious with new vaccination campaigns. And Sanofi, Novartis and others want local companies under their wings that can satisfy that demand. These Third World vaccine companies are also a low-cost center for new vaccine development.&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;Tianyuan is small but growing fast, doubling sales from 2006 to 2008. And Novartis says that it intends to "expand Tianyuan's product portfolio and R&amp;amp;D pipeline" while using it as a conduit for its existing lineup of vaccines. That's all good reason for Novartis to forecast continued double-digit growth for its vaccine business in the years to come.&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;- read the&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" href="http://online.wsj.com/article/SB10001424052748704013004574515153880532422.html?mod=rss_Deals_and_Deal_Makers"&gt;story&lt;/a&gt;&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;from the&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;em&gt;Wall Street Journal&lt;/em&gt;&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;&lt;strong&gt;Related Articles:&lt;/strong&gt;&lt;br /&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" href="http://www.fiercepharma.com/story/novartis-wants-china-its-no-3-market/2009-11-04"&gt;Novartis wants China as its No. 3 market&lt;/a&gt;&lt;br /&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" href="http://www.fiercepharma.com/story/novartis-invests-1b-china-r-d-ops/2009-11-03"&gt;Novartis investing $1B in China R&amp;amp;D ops&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;/a&gt;&lt;br /&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" href="http://www.fiercepharma.com/story/big-pharma-eyes-rural-india-growth/2009-03-19"&gt;Big Pharma eyes rural India for growth&lt;/a&gt;&lt;br /&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" target="_parent" href="http://www.fiercepharma.com/story/novartis-hiring-mood-china/2009-04-13"&gt;Novartis in hiring mood - in China&lt;/a&gt;&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" target="_parent" href="http://www.fiercepharma.com/story/novartis-hiring-mood-china/2009-04-13"&gt;&lt;br /&gt;&lt;/a&gt;&lt;/p&gt;&lt;span&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" href="http://www.fiercevaccines.com/story/big-pharma-maps-out-global-vaccine-strategy/2009-11-05#ixzz0WKrkAARQ"&gt;&lt;/a&gt;&lt;/span&gt;&lt;p&gt;By: &lt;em&gt;&lt;a href="http://www.fiercevaccines.com/story/big-pharma-maps-out-global-vaccine-strategy/2009-11-05" target="_blank"&gt;John Carroll&lt;/a&gt;&lt;/em&gt; for &lt;a href="http://www.fiercevaccines.com/"&gt;&lt;img border="0" alt="Tech Watch" src="http://www.fiercevaccines.com/images/fiercevaccines.gif" /&gt;&lt;/a&gt;.&lt;/p&gt;</crossTech:Body>
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               <dc:creator>John Carroll</dc:creator>
               <link>http://lifesciencesinsight.com/article.html?a=Big-Pharma-maps-out-a-global-vaccine-strategy</link>
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               <pubDate>Mon, 09 Nov 2009 05:00:00 GMT</pubDate>
               <crossTech:date>11/9/2009</crossTech:date>
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               <title>Report says IT vendors should target CFOs in 'changed sales environment'</title>
               <description>A new report by Gartner, Inc., recommends that information technology and service providers plan their 2010 marketing campaigns, sales and service engagements with clearer value propositions aimed at the chief financial officer and strategic business unit leaders.</description>
               <crossTech:Body>&lt;p style="font-family: arial,helvetica,sans-serif; font-style: normal; font-variant: normal; font-weight: normal; font-size: 12px; font-size-adjust: none; font-stretch: normal; color: rgb(0, 0, 0); line-height: 1.5;"&gt;A new report by Gartner, Inc., recommends that information technology and service providers plan their 2010 marketing campaigns, sales and service engagements with clearer value propositions aimed at the chief financial officer and strategic business unit leaders.&lt;/p&gt;&lt;p style="font-family: arial,helvetica,sans-serif; font-style: normal; font-variant: normal; font-weight: normal; font-size: 12px; font-size-adjust: none; font-stretch: normal; color: rgb(0, 0, 0); line-height: 1.5;"&gt;The IT research and advisory firm predicts a 6.8 percent decline in 2009 worldwide industry vertical market IT spending from 2008. The total 2009 projections amount to $2.28 trillion.&lt;/p&gt;&lt;p style="font-family: arial,helvetica,sans-serif; font-style: normal; font-variant: normal; font-weight: normal; font-size: 12px; font-size-adjust: none; font-stretch: normal; color: rgb(0, 0, 0); line-height: 1.5;"&gt;According to Gartner, healthcare IT spending in 2009 will total $79.8 billion, down from $85.1 billion in 2008, a drop-off of 6.2 percent. But the firm's analysts predict the overall IT market will return to growth in 2010, when it will grow at 2.3 percent to reach $2.34 trillion.&lt;/p&gt;&lt;p style="font-family: arial,helvetica,sans-serif; font-style: normal; font-variant: normal; font-weight: normal; font-size: 12px; font-size-adjust: none; font-stretch: normal; color: rgb(0, 0, 0); line-height: 1.5;"&gt;Gartner says the new economic conditions mean that IT vendors will have to deploy "account teams composed and trained to execute in a changed sales environment" and may have to target IT marketing more directly at CFOs rather than at an organization's IT leadership.&lt;/p&gt;&lt;p style="font-family: arial,helvetica,sans-serif; font-style: normal; font-variant: normal; font-weight: normal; font-size: 12px; font-size-adjust: none; font-stretch: normal; color: rgb(0, 0, 0); line-height: 1.5;"&gt;"This deep and prolonged recession has the potential to create a new market environment with stronger spheres of financial and business influence in many industries' IT buying centers," said Kenneth Brant, research director at Gartner. "Vendors should develop and/or expand financial models for project justification and sales training on selling to the financial buyer and business leader."&lt;/p&gt;&lt;p style="font-family: arial,helvetica,sans-serif; font-style: normal; font-variant: normal; font-weight: normal; font-size: 12px; font-size-adjust: none; font-stretch: normal; color: rgb(0, 0, 0); line-height: 1.5;"&gt;Gartner predicts financial services will lead all industry vertical markets, with IT spending totalling $502.6 billion in 2009. However, the firm notes that this segment will decline 8.3 percent. The agriculture, mining and construction market will experience the steepest decline in IT spending this year, by 9.2 percent.&lt;/p&gt;&lt;p style="font-family: arial,helvetica,sans-serif; font-style: normal; font-variant: normal; font-weight: normal; font-size: 12px; font-size-adjust: none; font-stretch: normal; color: rgb(0, 0, 0); line-height: 1.5;"&gt;The national and international government industry will show the slowest decline in IT spending as revenue decreases 3.6 percent.&lt;/p&gt;&lt;p style="font-family: arial,helvetica,sans-serif; font-style: normal; font-variant: normal; font-weight: normal; font-size: 12px; font-size-adjust: none; font-stretch: normal; color: rgb(0, 0, 0); line-height: 1.5;"&gt;"Our expectations for when the market will return to positive growth in IT spending - and for how strong that growth will be - vary significantly by industry sector, with the majority of industries expected to enter a period of sustained, positive growth in 2011," said Brant. "The three largest industry segments in 2008 - financial services, manufacturing and government - will remain the largest industry markets worldwide through 2013."&lt;em&gt;&lt;br /&gt;&lt;/em&gt;&lt;/p&gt;&lt;p&gt;By: &lt;em&gt;&lt;a href="http://www.healthcareitnews.com/news/report-says-it-vendors-should-target-cfos-changed-sales-environment" target="_blank"&gt;Richard Pizzi&lt;/a&gt;&lt;/em&gt; for &lt;a href="http://www.healthcareitnews.com/"&gt;&lt;img border="0" alt="Tech Watch" src="http://www.healthcareitnews.com/sites/healthcareitnews.com/files/medtech_logo.gif" /&gt;&lt;/a&gt;.&lt;/p&gt;</crossTech:Body>
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               <dc:creator>Richard Pizzi</dc:creator>
               <link>http://lifesciencesinsight.com/article.html?a=Report-says-IT-vendors-should-target-CFOs-in-'changed-sales-environment'</link>
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               <pubDate>Mon, 09 Nov 2009 05:00:00 GMT</pubDate>
               <crossTech:date>11/9/2009</crossTech:date>
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               <title>Pfizer, IBM push mashup envelope</title>
               <description>As IBM prepares to unveil a mashup service and the latest edition of its Mashup Center software, Pfizer is revealing more about its use of the IT-staff-relieving, business-unit empowering technology.</description>
               <crossTech:Body>&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;As IBM prepares to unveil a mashup service and the latest edition of its Mashup Center software, Pfizer is revealing more about its use of the IT-staff-relieving, business-unit empowering technology.&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;Big Blue's Mashup Center upgrade, due later this month, is expected to expand the types of data sources that users can tap. Microsoft SharePoint, WebSphere MQ and FileNet integration will allow businesses to generate feeds for mashing with other data sources. Collaboration features will let businesses create mashup page collections. The Cognos 8 Mashup Service, to be launched with the center upgrade, is an application programming interface (API) that exposes content from Cognos 8 Business Intelligence as an online service for use in other applications and mashups.&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;Separately, Pfizer has noted that successful mashup development requires a culture shift. "In an industry so rooted in scientific research, employees can get very attached to the data they generate. A cultural shift toward open data sharing had to take place," says a company research fellow in a&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;em&gt;SearchSOA&lt;/em&gt;&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;article. "In the IT department, the culture shift was one of empowering the business users. But the IT department needed first to be persuaded that not all infrastructure tools are IT tools."&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;And as reported earlier, Pfizer uses a business intelligence mashup supporting ad-hoc query, forecasting, planning and modeling for its pharmaceutical sciences product executives making investment decisions.&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;-&amp;nbsp;here's the&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" href="http://www.fiercebiotech.com/press-releases/new-ibm-mashup-capabilities-bring-business-analytics-desktop"&gt;IBM announcement&lt;/a&gt;&lt;br /&gt;-&amp;nbsp;see the Pfizer culture-shift&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" href="http://searchsoa.techtarget.com/news/article/0,289142,sid26_gci1372691,00.html"&gt;story&lt;/a&gt;&lt;br /&gt;-&amp;nbsp;here's our earlier Pfizer mashup&lt;span class="Apple-converted-space"&gt;&amp;nbsp;&lt;/span&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" href="http://www.fiercebiotechit.com/story/mashup-aids-pfizer-investment-execs/2009-07-30"&gt;coverage&lt;/a&gt;&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;&lt;strong&gt;Related Articles:&lt;br /&gt;&lt;/strong&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" target="_parent" href="http://www.fiercebiotech.com/story/ibm-targets-faster-cheaper-sequencing/2009-10-06?utm_medium=rss&amp;amp;utm_source=rss&amp;amp;cmp-id=OTC-RSS-FB0"&gt;IBM targets faster, cheaper sequencing&lt;/a&gt;&lt;br /&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" target="_parent" href="http://www.fiercebiotechit.com/story/ibm-readies-cloud-business/2009-06-19"&gt;IBM readies cloud for business&lt;/a&gt;&lt;/p&gt;&lt;p style="margin: 0px 0px 5px; padding: 0px;"&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" target="_parent" href="http://www.fiercebiotechit.com/story/ibm-readies-cloud-business/2009-06-19"&gt;&lt;br /&gt;&lt;/a&gt;&lt;/p&gt;&lt;span&gt;&lt;a style="text-decoration: none; color: rgb(42, 51, 132);" href="http://www.fiercebiotechit.com/story/pfizer-ibm-push-mashup-envelope/2009-11-02#ixzz0WKpOxPQZ"&gt;&lt;/a&gt;&lt;/span&gt;&lt;p&gt;By: &lt;em&gt;&lt;a href="http://www.fiercebiotechit.com/story/pfizer-ibm-push-mashup-envelope/2009-11-02" target="_blank"&gt;George miller&lt;/a&gt;&lt;/em&gt; for &lt;a href="http://www.fiercebiotechit.com/"&gt;&lt;img border="0" alt="Tech Watch" src="http://www.fiercebiotechit.com/public/logos/fiercebiotechit245.gif" /&gt;&lt;/a&gt;.&lt;/p&gt;</crossTech:Body>
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               <dc:creator>George Miller</dc:creator>
               <link>http://lifesciencesinsight.com/article.html?a=Pfizer,-IBM-push-mashup-envelope</link>
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               <pubDate>Mon, 09 Nov 2009 05:00:00 GMT</pubDate>
               <crossTech:date>11/9/2009</crossTech:date>
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